Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure

Neuropharmacology
E BarbierMickaël Naassila

Abstract

Exposure to ethanol early in life can have long-lasting implications on brain function and drug of abuse response later in life. The present study investigated in rats, the long-term consequences of pre- and postnatal (early life) ethanol exposure on drug consumption/reward and the molecular targets potentially associated with these behavioral alterations. Since a relationship has been demonstrated between heightened drugs intake and susceptibility to drugs-induced locomotor activity/sensitization, anxiolysis, we tested these behavioral responses, depending on the drug, in control and early life ethanol-exposed animals. Our results show that progeny exposed to early life ethanol displayed increased consumption of ethanol solutions and increased sensitivity to cocaine rewarding effects assessed in the conditioned place preference test. Offspring exposed to ethanol were more sensitive to the anxiolytic effect of ethanol and the increased sensitivity could, at least in part, explain the alteration in the consumption of ethanol for its anxiolytic effects. In addition, the sensitivity to hypothermic effects of ethanol and ethanol metabolism were not altered by early life ethanol exposure. The sensitization to cocaine (20 mg/kg) and ...Continue Reading

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Citations

Mar 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emmanuelle Simon O'BrienMickaël Naassila
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Christine J FontaineBrian R Christie
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Oct 26, 2016·Addiction Biology·Benoît Silvestre de FerronOlivier Pierrefiche
Oct 7, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kathryn HausknechtRoh-Yu Shen
Jan 8, 2018·Neurochemical Research·Mickaël Naassila, Olivier Pierrefiche
Nov 11, 2019·British Journal of Pharmacology·Lídia CantacorpsOlga Valverde
Sep 21, 2020·The International Journal of Neuropsychopharmacology·Leticia Duart-CastellsElena Escubedo
Jul 21, 2021·Biological Psychiatry·Sebastiano Bariselli, David M Lovinger

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