Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders

Brain Research
Morgan L KleiberShiva M Singh

Abstract

Many women continue to consume low to moderate quantities of alcohol during pregnancy, which can result in the variable neurobehavioural effects in the absence of physiological abnormalities that characterize fetal alcohol spectrum disorders (FASD). Previously, we reported that a mouse model for FASD based on voluntary maternal ethanol consumption throughout gestation resulted in offspring that showed mild developmental delay, anxiety-related traits, and deficits in spatial learning. Here, we extend this model by evaluating the gene expression changes that occur in the adult brain of C57BL/6J mice prenatally exposed to ethanol via maternal preference drinking. The results of two independent expression array experiments indicate that ethanol induces subtle but consistent changes to global gene expression. Gene enrichment analysis showed over-represented gene ontology classifications of cellular, embryonic, and nervous system development. Molecular network analysis supported these classifications, with significant networks related to cellular and tissue development, free radical scavenging, and small molecule metabolism. Further, a number of genes identified have previously been implicated in FASD-relevant neurobehavioural phenot...Continue Reading

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Citations

Jul 6, 2014·Journal of Developmental Origins of Health and Disease·A M Vaiserman
May 25, 2013·Reproductive Toxicology·Lorena CanalesRachel E Neal
Jul 17, 2015·Epigenomics·Benjamin I LauferShiva M Singh
Feb 24, 2015·Alcoholism, Clinical and Experimental Research·Feng C Zhou
Feb 17, 2015·Alcoholism, Clinical and Experimental Research·Alexandre A LussierJoanne Weinberg
Oct 30, 2014·Frontiers in Genetics·Shiva M SinghJoachim Kapalanga
Jul 1, 2016·Epigenetics & Chromatin·Elodie Portales-CasamarMichael S Kobor
Oct 4, 2017·Nucleic Acids Research·Laurence A BrownStuart N Peirson
Jan 26, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Berardino PetrelliGeoffrey G Hicks
Dec 28, 2018·Alcoholism, Clinical and Experimental Research·Emilie T ThébergeKristin M Hamre
Nov 7, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Eric Chater-DiehlShiva M Singh
Jul 1, 2014·Reviews in the Neurosciences·Ioannis BakoyiannisDespina Perrea
Dec 27, 2016·Frontiers in Neuroscience·Argelia E Rojas-MayorquínDaniel Ortuño-Sahagún
May 4, 2017·Nature Communications·Seiji IshiiKazue Hashimoto-Torii
Jun 7, 2018·G3 : Genes - Genomes - Genetics·Tatiana V MorozovaRobert R H Anholt
Feb 25, 2017·Epigenomics·Alexandre A LussierMichael S Kobor
Jan 1, 2021·Journal of Analytical Toxicology·Mukaddes GürlerReinhard B Dettmeyer
Dec 18, 2020·Journal of Neurodevelopmental Disorders·Shahid MohammadMasaaki Torii
Jul 19, 2020·Neuroscience and Biobehavioral Reviews·Craig D C BaileyCheryl M McCormick
Jun 22, 2021·Frontiers in Molecular Neuroscience·Bonnie AlberryShiva M Singh

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