Long-term anergy in orally tolerized mice is linked to decreased B7.2 expression on B cells

Immunobiology
Eliana A FutataMaria Notomi Sato

Abstract

Durable antigen (Ag)-specific T- and B-cell anergy induced by oral tolerance is an attractive strategy for immunotherapy of allergic diseases. Here, we address the lasting effect of oral tolerance induction in naïve or primed mice to ovalbumin (OVA) on antibody production. Single feeding with OVA prior to immunization or double feeding, before and after Ag priming, in A/Sn mice, induced a long-lasting suppression of IgE, IgG1 and IgG2a responses up to 8 months after immunization. In contrast, primed-fed mice had transient IgE inhibition. Naive and double-treated mice showed marked Ag-specific unresponsiveness and scarce cytokines production. Inhibition of IL-2 and IFN-gamma secretion in naïve-fed mice were restored in the presence of anti-CD28 mAb plus Ag stimulation. The durable inhibition of Ab production in OVA-fed mice was related to the persistent decrease of B7.2 expression on B cells. Ag feeding in naive and primed status may be a prophylactic measure to avoid later Ag sensitization.

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Citations

Jan 14, 2009·Trends in Immunology·J P McFaddenI Kimber
Oct 22, 2008·Respiratory Physiology & Neurobiology·Viviane C Ruiz SchützIolanda F L C Tibério
Apr 26, 2017·Human Vaccines & Immunotherapeutics·Fábio da Ressureição SgnottoJefferson Russo Victor
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Aug 8, 2020·Vaccines·Thamires Rodrigues de Sousa, Jefferson Russo Victor
Aug 8, 2018·Allergologia et immunopathologia·Aline Aparecida de Lima LiraJefferson Russo Victor

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