PMID: 8638832Apr 1, 1996Paper

Long-term angiotensin-converting enzyme inhibitor treatment attenuates adrenergic responsiveness without altering hemodynamic control in patients undergoing cardiac surgery

Anesthesiology
M LickerD R Morel

Abstract

The sympathoadrenal and the renin-angiotensin systems are involved in blood pressure regulation and are known to be markedly activated during cardiac surgery. Because unexpected hypotensive events have been reported repeatedly during anesthesia in patients chronically treated with angiotensin-converting enzyme (ACE) inhibitors, the authors questioned whether renin-angiotensin system blockade would alter the hemodynamic control through attenuation of the endocrine response to surgery and/or through attenuation of the pressor effects of exogenous catecholamines. Patients with preserved left ventricular function undergoing mitral valve replacement or coronary revascularization were divided into two groups according to preoperative drug therapy: patients receiving ACE inhibitors for at least 3 months (ACEI) group, n = 22) and those receiving other cardiovascular drug therapy (control group, n = 19). Anesthesia was induced using fentanyl and midazolam. Systemic hemodynamic variables were recorded before surgery, after anesthesia induction, during sternotomy, after aortic cross-clamping, after aortic unclamping, as well as after separation from cardiopulmonary bypass (CPB) and during skin closure. Blood was sampled repeatedly up to 2...Continue Reading

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Citations

Jul 10, 2012·Annals of Cardiac Anaesthesia·Marc LickerKarim Bendjelid
Aug 12, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M LickerD R Morel
Jun 1, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M LickerD R Morel
May 13, 2009·American Journal of Therapeutics·Anna Maria ArroyoLouise W Kao
Oct 3, 2006·Current Opinion in Anaesthesiology·M Licker, D R Morel
Jun 24, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Silas W SmithHoward A Greller
Aug 3, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Berend Mets
Mar 4, 2011·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Xiumei SunRobert E Molyneaux
Mar 1, 2011·The Annals of Thoracic Surgery·Marc LickerCigdem Inan
Aug 8, 2008·Best Practice & Research. Clinical Anaesthesiology·Matthias LangeAndrea Morelli
May 19, 2004·Fundamental & Clinical Pharmacology·Edmundo P Souza NetoCatherine Cerutti
Mar 24, 1998·Journal of Cardiothoracic and Vascular Anesthesia·S L Aronson, F A Hensley
Aug 1, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yiran Zhang, Liang Ma
Jun 21, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Meena BhatiaPriya A Kumar
Feb 25, 2005·Anesthesia and Analgesia·Thomas ComfereDavid O Warner
Aug 26, 2006·Anesthesia and Analgesia·Leanne Groban, John Butterworth
Dec 9, 2004·Asian Cardiovascular & Thoracic Annals·Mohan P DevbhandariSai U Prasad
Sep 2, 2009·Journal of Cardiovascular Pharmacology and Therapeutics·Mehran ShahzamaniPeyman Nejatbakhsh Azadani
Oct 17, 2001·Circulation·A C SchoolwerthUNKNOWN Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Assoc
Oct 15, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jian-Zhong SunHong Liu
Mar 11, 1999·Anesthesia and Analgesia·M Licker, A Schweizer
Nov 30, 1999·Anesthesia and Analgesia·P ColsonP Coriat

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