Long-term angiotensin-converting enzyme inhibition with fosinopril improves depressed responsiveness to Ca2+ in myocytes from aortic-banded rats

Circulation
Y KagayaB H Lorell

Abstract

We have previously shown that long-term ACE inhibition with fosinopril prolongs survival and improves ventricular function despite persistent severe left ventricular pressure overload in ascending aortic-banded rats with left ventricular hypertrophy during the transition from compensation to failure. To study the cellular mechanism of the effects of long-term ACE inhibition on the modification of the transition to failure in pressure-overload hypertrophy, we measured simultaneous intracellular Ca2+ transients and myocyte shortening in isolated left ventricular myocytes from fosinopril-treated aortic-banded rats (n = 9), untreated aortic-banded rats (n = 9), and normal age-matched control rats (n = 10). Fosinopril therapy was begun 6 weeks after banding and was continued until week 21 after banding, when the animals were killed. Collagenase-dissociated myocytes loaded with indo 1-AM were paced at 3 Hz at 36 degrees C and superfused at [Ca2+]o of 0.6, 1.2, and 3.0 mmol/L. In myocytes from untreated aortic-banded rats, peak systolic [Ca2+]i was higher than in control myocytes, and the relationship between myocyte shortening and [Ca2+]i was depressed relative to control myocytes, implicating impaired responsiveness to Ca2+. Long-te...Continue Reading

References

Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·B DahlöfL Hansson
Jun 11, 1989·The American Journal of Physiology·J Y CheungR C Scaduto
Apr 1, 1988·IEEE Transactions on Bio-medical Engineering·B W SteadmanJ H Bridge
Apr 1, 1984·The American Journal of Cardiology·Y NakashimaR C Tarazi
Dec 1, 1981·Journal of Molecular and Cellular Cardiology·K SchwartzB Swynghedauw

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Citations

Oct 13, 1998·Journal of the American College of Cardiology·P S DouglasB H Lorell
Jul 10, 1999·Journal of the American College of Cardiology·E O WeinbergB H Lorell
Dec 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S K Wattanapitayakul, J A Bauer
Aug 8, 2006·Journal of Cardiovascular Pharmacology·Robert J Henning, Javier Cuevas
Apr 18, 2007·Artificial Organs·Ligia H ArrudaIsmar N Cestari
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M I MiyamotoR J Hajjar
Sep 20, 2011·Pflügers Archiv : European journal of physiology·Rashad J BelinPieter P de Tombe
Nov 3, 2009·Vascular Pharmacology·Kenta ItoHiroaki Shimokawa
Jul 4, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Rashad J BelinPieter P de Tombe
Aug 2, 2019·The Journal of General Physiology·Vani S RavichandranMargaret V Westfall
May 12, 1998·The American Journal of Physiology·L S MaierD M Bers
Apr 12, 2002·Physiological Genomics·Federica Del MonteRoger J Hajjar
Sep 29, 2007·The Journal of Pharmacology and Experimental Therapeutics·Vlad CiobotaruDamien Logeart
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Z SuW H Barry
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S Y BoatengK R Boheler
Mar 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Dana KučerováUwe Kirchhefer

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