Long-Term Anticoagulation in Secondary Ischemic Stroke Prevention: The Prospective Multicenter RESTAIC Registry

Frontiers in Neurology
Raquel Gutiérrez-ZúñigaExuperio Díez-Tejedor

Abstract

Background and Objective: Oral anticoagulation (OAC) for secondary stroke prevention is recommended in atrial fibrillation (AF) and other sources of cardioembolic stroke. Our objectives were to explore the differences in ischemic and hemorrhagic events when using OAC for secondary stroke prevention according to the type of anticoagulant treatment and to analyze the number and reasons for OAC switches during long-term follow-up. Methods: Ischemic stroke (IS) patients who were discharged on OAC for secondary stroke prevention from January 2014 to October 2017 were recruited in a prospective, multicenter, hospital-based registry. Follow-up at 3 months was scheduled at the outpatient clinic with subsequent annual phone interviews for 3 years. Patients were classified into three study groups according to OAC at discharge: Vitamin K antagonist (VKA), Factor Xa inhibitor (FXa), or direct thrombin inhibitor (DTI). We compared stroke recurrences, intracranial hemorrhage, major bleeding, and all-cause mortality during the follow-up. We recorded any switches in OAC and the main reasons for the change. Results: A total of 241 patients were included. An anticoagulant was indicated in the presence of a source of cardioembolic stroke in 240 p...Continue Reading

References

Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Jun 23, 2016·Journal of Thrombosis and Thrombolysis·Manuel CappellariPaolo Bovi
Jul 28, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kosmas MachaMartin Köhrmann
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Oct 4, 2016·Journal of Thrombosis and Thrombolysis·David J SeiffgeStefan Engelter
Dec 17, 2016·Journal of the American College of Cardiology·Benjamin A SteinbergUNKNOWN ORBIT-AF Investigators and Patients
Jun 20, 2017·American Heart Journal·Benjamin A SteinbergUNKNOWN Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigators and Patients
Dec 26, 2017·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Taizen NakaseTatsuya Ishikawa
Jun 5, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Sohei YoshimuraUNKNOWN SAMURAI Study Investigators
Aug 7, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuo OkumuraUNKNOWN SAKURA AF Registry Investigators
Aug 29, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G Zapata-WainbergUNKNOWN researchers in the ANITA-FA study
Mar 12, 2019·Stroke; a Journal of Cerebral Circulation·Kosmas MachaBernd Kallmünzer
Mar 26, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Vanessa M SilvaCelia C Strunz
Apr 14, 2019·Annals of Neurology·David J SeiffgeUNKNOWN CROMIS-2, RAF, RAF-DOAC, SAMURAI, NOACISP LONGTERM, Erlangen and Verona registry collaborators
Apr 21, 2019·Neurology·Joan Martí-FàbregasUNKNOWN HERO study investigators
Jun 5, 2019·Revista Española De Cardiología·Manuel Anguita SánchezUNKNOWN FANTASIIA study investigators
Aug 10, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Karl Georg HaeuslerMatthias Endres
Sep 5, 2019·Cerebrovascular Diseases·Armin MarschBernd Kallmünzer
Nov 5, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Satoshi SudaKazumi Kimura

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.