Long-term atorvastatin treatment decreases heart maximal oxygen consumption and its vulnerability to in vitro oxidative stress in Watanabe heritable hyperlipidemic rabbit

Canadian Journal of Physiology and Pharmacology
Florine TissierAline Amérand

Abstract

Statins are currently used in prevention of cardiovascular diseases in high-risk populations, and could be considered in primary prevention. However, few studies are available on the long-term effects of low doses of statins, especially on mitochondrial function and reactive oxygen species (ROS) metabolism at cardiac level. This study aimed to determine potential effects of a long-term atorvastatin treatment, at low-dose concentration, on the myocardium mitochondrial respiration. Thirty-four Watanabe rabbits were treated or not with atorvastatin (2.5 mg·kg-1·day-1) from the age of 3 to 12 months. Every 3 months, proton leak, basal (V0), and maximal (Vmax) mitochondrial respiration on cardiac permeabilized fibers were measured. Additionally, the vulnerability to ROS, cardiac enzymatic antioxidant defenses, and oxidative damage (lipoperoxidation) were analyzed. Proton leak increased over the duration of the experiment (up to 60% from Vmax at 12 months). Moreover, the statin treatment induced a decrease of Vmax and a decrease of ROS susceptibility of cardiac mitochondria. However, the lipoperoxidation and the antioxidant defenses were not dependent on the presence of statin treatment, or on its duration. This is the first study sh...Continue Reading

References

Jul 1, 1992·Pediatric Research·T LetellierJ P Mazat
Aug 1, 1991·The American Journal of Physiology·L L JiE Wu
Jan 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L M BujaM S Brown
Mar 29, 2001·Journal of Pineal Research·D Acuña-CastroviejoR J Reiter
Aug 4, 2001·Pflügers Archiv : European journal of physiology·B WalshK Sahlin
Nov 10, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S W RossB L Christensen
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Aug 3, 2002·Hypertension·Sandrine DelboscBernard Jover
Mar 14, 2003·Pflügers Archiv : European journal of physiology·A P RussellP Schrauwen
Apr 18, 2003·Endothelium : Journal of Endothelial Cell Research·Sven Wassmann, Georg Nickenig
Jul 1, 1956·Journal of Gerontology·D HARMAN
Jun 17, 2004·Circulation·Jean Davignon
Sep 18, 2004·Trends in Neurosciences·Gustavo Barja
Oct 30, 2004·Stroke; a Journal of Cerebral Circulation·Pierre AmarencoPierre-Jean Touboul
Jan 12, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sharon JudgeChristiaan Leeuwenburgh
Apr 15, 2005·Redox Report : Communications in Free Radical Research·Aline AmérandChristine Cann-Moisan
May 10, 2005·Science·Samuel E SchrinerPeter S Rabinovitch
Jun 9, 2005·Journal of Atherosclerosis and Thrombosis·Hiroshi MabuchiJunji Kobayashi
Aug 16, 2005·Cell Metabolism·Martin D Brand, Telma C Esteves
Feb 1, 2007·Redox Report : Communications in Free Radical Research·G ServiddioG Vendemiale
Apr 29, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Qian Zhou, James K Liao
Oct 18, 2011·Pharmacological Reports : PR·Michał TomaszewskiStanisław J Czuczwar
Dec 14, 2011·The New England Journal of Medicine·Cynthia A JackeviciusHarlan M Krumholz
Jan 25, 2012·Toxicology and Applied Pharmacology·P SirventJ Mercier
Apr 14, 2012·Circulation Research·Dao-Fu DaiZoltan Ungvari
Jun 12, 2013·Redox Report : Communications in Free Radical Research·Karelle LéonErwan L'Her
Mar 4, 2014·Journal of Atherosclerosis and Thrombosis·Shen LiJianglin Fan
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christopher B Newgard, Jeffrey E Pessin
Sep 23, 2014·Redox Report : Communications in Free Radical Research·Firas FarhatChristine Moisan
Jun 4, 2015·The New England Journal of Medicine·Christopher P CannonUNKNOWN IMPROVE-IT Investigators
Jan 7, 2017·Circulation Research·Adam OesterleJames K Liao

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