Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma

Pulmonary Pharmacology & Therapeutics
Ji Young KangJin Woo Kim

Abstract

We investigated the effect of long-term treatment with azithromycin on the pathogenesis of chronic asthma with airway remodeling. Six-week-old-BALB/c mice were sensitized with ovalbumin (OVA) combined with lipopolysaccharide (LPS) for 1 month, then challenged with OVA for 3 months. Azithromycin at 75 mg/kg was administered via oral gavage five times a week during the challenge period. Inflammatory cells, T helper 2 cytokines in bronchoalveolar lavage fluid (BAL) fluid, and airway hyperresponsiveness (AHR) were measured. Parameters related to airway remodeling were evaluated. The levels of neutrophil elastase, Interleukin (IL)-8, and BRP-39 (human homologue YKL-40) were assessed. The expression of MAPK and NF-κB signaling were investigated. Long-term treatment with azithromycin improved AHR and airway inflammation compared with the OVA and the OVA/LPS groups. The concentrations of IL-5 and IL-13 in the OVA/LPS group decreased significantly after azithromycin administration. The levels of neutrophil elastase and IL-8, as surrogate markers of neutrophil activation, were reduced in the azithromycin group compared with the OVA/LPS group. Goblet cell hyperplasia and the smooth muscle thickening of airway remodeling were attenuated af...Continue Reading

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Citations

Jan 21, 2019·Journal of Cellular and Molecular Medicine·Bao-Ping TianWei Cui
Dec 11, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hironori SadamatsuNaoko Sueoka-Aragane
Aug 3, 2019·The Veterinary Record·Sophie Mainguy-SeersJean-Pierre Lavoie
Oct 28, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Kai WenJing Sun
Oct 31, 2021·Pharmacological Reviews·Jennifer A KrickerMichael J Parnham

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