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Long-Term Balancing Selection in LAD1 Maintains a Missense Trans-Species Polymorphism in Humans, Chimpanzees, and Bonobos

Molecular Biology and Evolution

Jan 22, 2015

João C TeixeiraAida M Andrés

Abstract

Balancing selection maintains advantageous genetic and phenotypic diversity in populations. When selection acts for long evolutionary periods selected polymorphisms may survive species splits and segregate in present-day populations of different species. Here, we investigate the role of...read more

Mentioned in this Paper

Leukocyte Adhesion Deficiency Type 1
Dermoepidermal Junction
Gene Expression
Equilibrium
Pan troglodytes
Pan paniscus
Immunoglobulin A Deficiency (Disorder)
Genes, vif
Genus Homo
Basement Membrane
13
1
47
Paper Details
References
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  • Citations13
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  • References47
  • Citations13
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Long-Term Balancing Selection in LAD1 Maintains a Missense Trans-Species Polymorphism in Humans, Chimpanzees, and Bonobos

Molecular Biology and Evolution

Jan 22, 2015

João C TeixeiraAida M Andrés

PMID: 25605789

DOI: 10.1093/molbev/msv007

Abstract

Balancing selection maintains advantageous genetic and phenotypic diversity in populations. When selection acts for long evolutionary periods selected polymorphisms may survive species splits and segregate in present-day populations of different species. Here, we investigate the role of...read more

Mentioned in this Paper

Leukocyte Adhesion Deficiency Type 1
Dermoepidermal Junction
Gene Expression
Equilibrium
Pan troglodytes
Pan paniscus
Immunoglobulin A Deficiency (Disorder)
Genes, vif
Genus Homo
Basement Membrane
13
1
47

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Intermediate Filaments

Intermediate filaments provide mechanical support for cells and tissues. Discover the latest research on intermediate filaments here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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Paper Details
References
  • References47
  • Citations13
12345
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  • Citations13
12
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