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Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

Human Genetics

Dec 1, 2010

Rachele CaglianiManuela Sironi

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Abstract

The human TRIM5 genes encodes a retroviral restriction factor (TRIM5α). Evolutionary analyses of this gene in mammals have revealed a complex and multifaceted scenario, suggesting that TRIM5 has been the target of exceptionally strong selective pressures, possibly exerted by recurrent w...read more

Mentioned in this Paper

Retroviridae Infections
Communicable Diseases
Retroviridae
Genetic Polymorphism
Pan troglodytes
Carrier Proteins
Evolution, Neutral
Bio-Informatics
Metazoa
Selection, Genetic
Paper Details
References
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    • Citations24
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  • Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

    Human Genetics

    Dec 1, 2010

    Rachele CaglianiManuela Sironi

    PMID: 20811909

    DOI: 10.1007/s00439-010-0884-6

    Abstract

    The human TRIM5 genes encodes a retroviral restriction factor (TRIM5α). Evolutionary analyses of this gene in mammals have revealed a complex and multifaceted scenario, suggesting that TRIM5 has been the target of exceptionally strong selective pressures, possibly exerted by recurrent w...read more

    Mentioned in this Paper

    Retroviridae Infections
    Communicable Diseases
    Retroviridae
    Genetic Polymorphism
    Pan troglodytes

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    Paper Details
    References
    • References47
    • Citations24
    • References47
    • Citations24
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