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Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

Human Genetics

Sep 3, 2010

Rachele CaglianiManuela Sironi

Abstract

The human TRIM5 genes encodes a retroviral restriction factor (TRIM5α). Evolutionary analyses of this gene in mammals have revealed a complex and multifaceted scenario, suggesting that TRIM5 has been the target of exceptionally strong selective pressures, possibly exerted by recurrent w...read more

Mentioned in this Paper

TRIM5gamma, human
Exertion
Transcription, Genetic
Bio-Informatics
HIV Infections
Equilibrium
Pan troglodytes
Primates
Nucleotides
TRIM5
Paper Details
References
  • References48
  • Citations24
12345
  • References48
  • Citations24
123

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Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

Human Genetics

Sep 3, 2010

Rachele CaglianiManuela Sironi

PMID: 20811909

DOI: 10.1007/s00439-010-0884-6

Abstract

The human TRIM5 genes encodes a retroviral restriction factor (TRIM5α). Evolutionary analyses of this gene in mammals have revealed a complex and multifaceted scenario, suggesting that TRIM5 has been the target of exceptionally strong selective pressures, possibly exerted by recurrent w...read more

Mentioned in this Paper

TRIM5gamma, human
Exertion
Transcription, Genetic
Bio-Informatics
HIV Infections
Equilibrium
Pan troglodytes
Primates
Nucleotides
TRIM5

Similar Papers Found In These Feeds

Parasite evolution

Parasite evolution involves the heritable genetic changes that a parasite accumulates during its life time. Discover the latest research on parasite evolution here.

Interferon Stimulated Genes

Interferon-stimulated gene products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. Discover the latest research on interferon-stimulated genes here.

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Paper Details
References
  • References48
  • Citations24
12345
  • References48
  • Citations24
123
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