Mar 20, 2012

Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice

Neurobiology of Disease
Maren KlugMaarten van den Buuse

Abstract

Psychiatric illnesses, such as schizophrenia, are most likely caused by an interaction between genetic predisposition and environmental factors, including stress during development. The neurotrophin, brain-derived neurotrophic factor (BDNF) has been implicated in this illness as BDNF levels are decreased in the brain of patients with schizophrenia. The aim of the present study was to assess the combined effect of reduced BDNF levels and postnatal stress, simulated by chronic young-adult treatment with the stress hormone, corticosterone. From 6 weeks of age, female and male BDNF heterozygous mice and their wild-type controls were chronically treated with corticosterone in their drinking water for 3 weeks. At 11 weeks of age, male, but not female BDNF heterozygous mice treated with corticosterone exhibited a profound memory deficit in the Y-maze. There were no differences between the groups in baseline prepulse inhibition (PPI), a measure of sensorimotor gating, or its disruption by treatment with MK-801. However, an increase in startle caused by MK-801 treatment was absent in male, but not female BDNF heterozygous mice, irrespective of corticosterone treatment. Analysis of protein levels of the NMDA receptor subunits NR1, NR2A, ...Continue Reading

  • References56
  • Citations21

References

  • References56
  • Citations21

Citations

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Corticosterone Assay
Inherited Factor II Deficiency
Neurotrophic Tyrosine Kinase Receptor Type 2
Immediate Recall
Ethanol
Behavior, Animal
Glucocorticoid inhalants for obstructive airway disease
Schizophrenia
C57BL/6 Mouse

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