Long-term benefits of insulin therapy and glycemic control in overweight and obese adults with type 2 diabetes

Journal of Diabetes and Its Complications
A Enrique Caballero

Abstract

Obesity and type 2 diabetes have reached epidemic proportions in the United States. Obese patients are at especially high risk for the development of metabolic syndrome, a clustering of metabolic abnormalities associated with insulin resistance that usually precede the development of cardiovascular disease. Overweight or obesity, along with insulin resistance, is frequently present in people with type 2 diabetes. A literature search of the PubMed and MEDLINE databases, using the terms diabetes, obesity, metabolic syndrome, glycemic control, antidiabetic therapy, and insulin, was performed. Articles published between 1985 and 2006 that examined diabetes management in the obese population were selected and reviewed. There is new evidence suggesting that tight glycemic control and earlier initiation of insulin therapy can improve outcomes in obese patients with type 2 diabetes, thereby reducing the risk for the development of both macrovascular and microvascular complications of the disease. Insulin also appears to exhibit anti-inflammatory effects, which may provide additional protection against the development of atherosclerosis. Despite the benefits of insulin therapy, many patients and physicians remain reluctant to start insu...Continue Reading

References

Sep 1, 1991·Diabetes Care·R R Henry, B Gumbiner
Dec 1, 1990·Diabetes Care·S Genuth
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y LeeR H Unger
Oct 1, 1996·Annals of Medicine·R C Turner, R R Holman
Jul 3, 1998·Diabetes Research and Clinical Practice·M Laakso
Aug 24, 1999·Annals of Internal Medicine·R A DeFronzo
Oct 8, 1999·Diabetic Medicine : a Journal of the British Diabetic Association
Nov 5, 1999·JAMA : the Journal of the American Medical Association·A MustW H Dietz
Feb 10, 2000·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research GroupDavid M Nathan
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 24, 2001·Archives of Internal Medicine·A E FieldG A Colditz
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Aug 14, 2002·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David S H Bell, Fernando Ovalle
Aug 28, 2002·Archives of Internal Medicine·Peter W F WilsonWilliam B Kannel
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Ali H MokdadJames S Marks
Jul 10, 2003·Diabetes Research and Clinical Practice·Raimund WeitgasserAnton Klingler
Oct 28, 2003·Diabetes Care·Matthew C RiddleUNKNOWN Insulin Glargine 4002 Study Investigators

❮ Previous
Next ❯

Citations

Jan 10, 2012·Journal of Diabetes and Its Complications·Chaoyang LiWayne H Giles
Oct 6, 2014·The American Journal of Medicine·Steven Edelman, Jeremy Pettus
Jan 12, 2011·Current Diabetes Reports·Kate MarshJennie Brand-Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.