PMID: 234266Jan 18, 1975

Long-term beta blockade: possible protection from myocardial infarction

British Medical Journal
K M FoxC P Aber

Abstract

The clinical behaviour of 90 patients on beta-blocking drugs for established coronary heart disease who were admitted to a coronary care unit with prolonged ischaemic myocardial pain was compared with that of 90 similar patients not on this therapy. Transmural myocardial infarction was confirmed in 30 of the patients on beta-blockers and in 62 controls. A diagnosis of myocardial necrosis without infarction was made in 20 patients on beta-blockers and in 14 controls. Coronary insufficiency was diagnosed in 40 patients on beta-blockers and in 14 controls. The incidence of simus bradycardia, hypotension, syncope, and radiological pulmonary oedema was similar in the two groups. Established beta-blockade, therefore, has not been shown to prejudice the outcome of patients with coronary heart disease admitted to hospital with prolonged ischaemic myocardial pain. On the contrary, it may protect some patients from the development of a myocardial infarction.

References

Jun 7, 1973·The New England Journal of Medicine·S J FischlR Gorlin
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Citations

Jun 15, 1976·European Journal of Clinical Pharmacology·G Ahlmark, H Saetre
Dec 18, 1978·European Journal of Clinical Pharmacology·W H Aellig
May 1, 1983·Progress in Cardiovascular Diseases·G J Goldman, A D Pichard
Mar 1, 1977·Progress in Cardiovascular Diseases·H S Mueller, S M Ayres
Jan 1, 1987·Progress in Cardiovascular Diseases·L M Buja, J T Willerson
Jan 1, 1983·The American Journal of Medicine·E BraunwaldP R Maroko
Jul 19, 1975·Lancet·C R KumanaJ Hamer
Sep 1, 1982·Journal of Clinical and Hospital Pharmacy·P L Weissberg
Mar 1, 1982·Journal of Clinical and Hospital Pharmacy·D M Burley
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·M J Kendall, S R Smith
Oct 1, 1979·Scottish Medical Journal·D G Lambie
Jan 1, 1976·Acta Medica Scandinavica. Supplementum·J M BarberM J Walsh
Jan 1, 1986·British Journal of Clinical Pharmacology·B N Prichard, C W Owens

Related Concepts

Adrenergic beta-Antagonists
SGOT - Glutamate oxaloacetate transaminase
Erythrocyte Sedimentation Rate Result
Coronary Care Units
Coronary Heart Disease
Electrocardiographic Recorders
Myocardial Infarction
Necrosis
Trasicor
Dalzic

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