PMID: 22579009May 15, 2012Paper

Long term bisphosphonate use in osteoporotic patients; a step forward, two steps back

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques
Pooneh Salari, Mohammad Abdollahi

Abstract

Bisphosphonates are the main class of drugs widely used in prevention and treatment of osteoporosis. Along with the beneficial effects, recent studies point to the harms of long-term treatment with bisphosphonates. The most relevant articles reporting serious adverse effects of bisphosphonates were selected and reviewed with the aim of assessing the risk-benefit of bisphosphonates. We searched PubMed, Web of Science, and Scopus using keywords bisphosphonates, risk of fracture, atrial fibrillation, osteonecrosis jaw, esophageal cancer, and adverse effects with no time limitation. We limited our s research to English articles. Our review shows that bisphosphonates reduce vertebral fractures in short term use while in long-term can cause osteonecrosis jaw, esophageal cancer, atrial fibrillation, and increase the risk of atypical fractures and probably adynamic bone disease. There is no consensus on the time limitation of bisphosphonate usage or its long term adverse effects. Thus, more studies on long-term side effects of bisphosphonates are highly recommended. In addition, new approaches for prevention and treatment of osteoporosis seem necessary. Prescribers should act cautionary and consider full assessment of risk-benefit and ...Continue Reading

Citations

Sep 1, 2017·Pharmacoepidemiology and Drug Safety·Ying-Ju OuYi-Hsin Yang
Nov 22, 2013·Journal of Cardiovascular Electrophysiology·Ingrid M BonillaCynthia A Carnes
Feb 9, 2017·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ozra Tabatabaei-MalazyBagher Larijani
Dec 12, 2012·Archives of Osteoporosis·Daniela KorthoewerUNKNOWN Endocrine and Metabolic Society of Singapore
Mar 11, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L HerreraG Trifiro
Oct 12, 2012·Acta neurochirurgica·Dae-Chul ChoJoo-Kyung Sung
Aug 9, 2016·Pharmacoepidemiology and Drug Safety·Ying-Ju OuYi-Hsin Yang
Oct 27, 2020·BioMed Research International·Rui PengGenglong Liu
May 29, 2021·International Journal of Nanomedicine·Sasmita SamalMamoni Dash

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