Long-term blood pressure variability and development of chronic kidney disease in type 2 diabetes

Journal of Hypertension
Francesca ViazziAMD-Annals Study Group

Abstract

Long-term visit-to-visit SBP variability (VVV) has been shown to predict cerebro-cardiovascular events and end-stage renal disease in chronic kidney disease (CKD) patients. Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain. We assessed the role of SBP VVV on the development of CKD in patients with type 2 diabetes (T2D) and hypertension in real life. Clinical records from 30 851 patients with T2D and hypertension, with normal estimated glomerular filtration rate (eGFR) and regular visits during a 4-year follow-up were analyzed. SBP variability was measured by three metrics: coefficient of variation; SD of the mean SBP and average absolute difference of successive values in each individual. CKD was defined as eGFR less than 60 and/or a reduction in eGFR at least 30% from baseline. Over the 4-year follow-up, 9.7% developed eGFR less than 60 and 4.5% an eGFR reduction at least 30% from baseline. Several clinical characteristics (older age, male sex, SBP, DBP, albuminuria, glycated hemoglobin, insulin treatment) were related to intraindividual SBP variability. Patients with VVV in the upper quintile showed an increased risk of developing both components of CKD [adjusted odds ratio (OR) 1.21, P...Continue Reading

References

May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Aug 16, 2011·Lancet·Andrew S Levey, Josef Coresh
Sep 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Biagio Di IorioAntonio Bellasi
Sep 28, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kei YokotaKazuomi Kario
Feb 13, 2013·Nature Reviews. Cardiology·Gianfranco ParatiGrzegorz Bilo
Mar 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Ciaran J McMullanJohn P Forman
Mar 29, 2013·Journal of Human Hypertension·E B LevitanP Muntner
Jan 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Salvatore De CosmoUNKNOWN AMD-Annals Study Group
Sep 6, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Salvatore De CosmoUNKNOWN AMD-Annals Study Group
Feb 26, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Jeff WhittlePaul Muntner
Sep 24, 2016·Journal of the American College of Cardiology·Elvira O GosmanovaCsaba P Kovesdy
Nov 9, 2016·Journal of the American Heart Association·Yook Chin ChiaSiew Mooi Ching
Sep 25, 2017·Journal of the American Heart Association·Francesca ViazziUNKNOWN AMD‐Annals Study Group

❮ Previous
Next ❯

Citations

May 19, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Youbao LiXianhui Qin
Jul 11, 2020·Journal of Hypertension·Francesca ViazziUNKNOWN and the AMD-Annals Study Group
Nov 13, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·Viktor Rotbain CurovicPeter Rossing
May 9, 2021·Cardiovascular Diabetology·Antonio Ceriello, Francesco Prattichizzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.