Long-term bowel dysfunction following low anterior resection.

Scientific Reports
Audrius DulskasNarimantas E Samalavicius

Abstract

Study aimed to assess long-term bowel function in patients who underwent low anterior resection for cancer five and more years ago. Patients who underwent low anterior resection for rectal cancer from 2010 to 2015 at National Cancer Institute were prospectively included in our study. They were interviewed using low anterior resection syndrome (LARS) score and Wexner questionnaire. We also assessed possible risk factors of postoperative bowel disorder. 150 patients were included in our study. Of them 125 (83.3%) were analysed. The median age at diagnosis was 62 years (40-79), and the average time of follow-up was 7.5 years (5-11). Overall, 58 (46.4%) patients had LARS, of them 33 (26.4%)-major LARS and 25 (20%)-minor LARS and 67 (53.6%) reported no LARS. Wexner score results were: normal in 43 (34.4%) patients, minor faecal incontinence-55 (44%), average faecal incontinence-18 (14.4%), complete faecal incontinence-9 (7.2%). 51 patients (40.8%) had tumour in the upper third rectum, 51 (40.8%)-in the middle and 23 (18.4%)-lower third. Preoperative (chemo)radiotherapy was the only significant risk factors for developing LARS in univariate analysis. Our study showed that only preoperative radiotherapy may be associated with more lat...Continue Reading

Associated Clinical Trials

Apr 18, 2019·Audrius Dulskas

References

Jan 1, 1993·Diseases of the Colon and Rectum·J M Jorge, S D Wexner
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·R WagmanP P Paty
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Sep 1, 2012·The Lancet Oncology·Catherine L C BryantChristopher L H Chan
Apr 20, 2013·Annals of Surgery·Therese JuulPeter Christensen
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GlimeliusUNKNOWN ESMO Guidelines Working Group
Jan 13, 2016·Techniques in Coloproctology·N E SamalaviciusG Smailyte
Oct 4, 2016·International Journal of Colorectal Disease·Alessandro SturialeAndrea Valeri
Feb 8, 2020·Diseases of the Colon and Rectum·Celia KeaneUNKNOWN LARS International Collaborative Group

❮ Previous
Next ❯

Citations

Mar 10, 2021·International Journal of Colorectal Disease·Athina A SamaraKonstantinos Tepetes
May 18, 2021·Contemporary Clinical Trials Communications·Virginia SunCynthia A Thomson
Aug 3, 2021·Surgical Oncology·Matthew FokDale Vimalachandran
Jul 16, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Deena HarjiQuentin Denost
Aug 20, 2021·International Journal of Colorectal Disease·Alfredo AnnicchiaricoPaolo Prosperi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT03920202

Software Mentioned

SPSS Statistics
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.