Long-term breast cancer survival in relation to the metastatic tumor burden in axillary lymph nodes

Breast Cancer Research and Treatment
Y AnderssonJana de Boniface

Abstract

The clinical significance of lymph node micrometastases and isolated tumor cells (ITCs) in breast cancer is still controversial. After a median follow-up of 52 months, a report from the Swedish Multicenter Cohort Study presented a worse cancer-specific and event-free survival for patients with micrometastases than node-negative individuals, but could not demonstrate a significant difference in overall survival (OS). Due to the tendency of breast cancer to relapse after more than 5-10 years, we now report the long-term survival of the cohort. Between September 2000 and January 2004, 3355 breast cancer patients were included in a prospective cohort. Sentinel lymph node biopsy was always performed. Patients were classified in four groups according to their overall nodal stage: node negative (N0, 2372), ITCs (113), micrometastases (123), and macrometastases (747). Kaplan-Meier survival estimates and Cox proportional hazard regression models were applied. Median follow-up was 156 months. Ten-year cancer-specific survival and OS were significantly lower in case of micrometastases than in N0 (84.7 vs. 93.5%, p = 0.001, and 75.5 vs. 84.2%, p = 0.046, respectively). In case of macrometastases, corresponding survival rates were 82.8 and ...Continue Reading

References

Mar 1, 1990·Journal of Surgical Oncology·A Meltzer
May 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J NixonJ R Harris
Mar 5, 2002·British Journal of Cancer·R R MillisI S Fentiman
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Eva SingletaryFrederick L Greene
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marco ColleoniGiuseppe Viale
Jun 1, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G P KuijtR M H Roumen
Jun 13, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M van der Heiden-van der LooP H M Peeters
Aug 11, 2006·Cancer·Douglas C MaibencoRichard K Severson
Jul 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D GrabauM Blichert-Toft
Sep 28, 2007·Annals of Surgical Oncology·Steven L ChenArmando E Giuliano
Jan 29, 2008·Journal of the American College of Surgeons·Charles E CoxDavid Boulware
Feb 9, 2008·Breast Cancer Research and Treatment·A J G MaaskantG A P Nieuwenhuijzen
Mar 1, 2008·International Journal of Clinical Oncology·Noriaki Wada, Shigeru Imoto
Mar 12, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee K TanHiram S Cody
Jul 4, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Pauline T TruongUNKNOWN Member of the International Nodal Ratio Working Group
Jul 26, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P D GobardhanT van Dalen
Aug 14, 2009·The New England Journal of Medicine·Maaike de BoerVivianne C G Tjan-Heijnen
Nov 13, 2009·PloS One·Hanna FredholmHenrik Lindman
Mar 2, 2010·Journal of the National Cancer Institute·M de BoerV C G Tjan-Heijnen
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yvette AnderssonLeif Bergkvist
Aug 4, 2010·Breast Cancer Research and Treatment·Adriana J Maaskant-BraatGrard A Nieuwenhuijzen
Dec 15, 2010·Annals of Surgical Oncology·Paul D GobardhanThijs van Dalen
Jan 21, 2011·The New England Journal of Medicine·Donald L WeaverNorman Wolmark
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jul 27, 2011·Surgical Oncology·Mohamed SalhabKefah Mokbel
Jul 28, 2011·JAMA : the Journal of the American Medical Association·Armando E GiulianoRichard Cote
Oct 9, 2012·Clinical Breast Cancer·Sadaf Jafferbhoy, Billy McWilliams
Feb 26, 2013·The British Journal of Surgery·Y AnderssonL Bergkvist
May 31, 2014·The Breast : Official Journal of the European Society of Mastology·Gilles HouvenaeghelUNKNOWN et al
Sep 3, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I MeattiniL Livi
Feb 11, 2015·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hitoshi Tsuda
Mar 14, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gilles HouvenaeghelEric Lambaudie
Nov 1, 2016·Breast Cancer Research and Treatment·Javaid IqbalSteven A Narod
Nov 9, 2017·The New England Journal of Medicine·Hongchao PanUNKNOWN EBCTCG

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Citations

Jun 5, 2019·Bioscience Reports·Si-Ying ZhouJin-Hai Tang
Feb 25, 2019·World Journal of Surgical Oncology·Hideo ShigematsuShinji Ozaki
Sep 10, 2019·Expert Review of Anticancer Therapy·Maryam Dosani, Pauline T Truong
Mar 28, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Wei-Rong ChenSan-Gang Wu
Apr 3, 2020·International Journal of Molecular Medicine·Chunlei YuanSijia Duan
Feb 6, 2020·Critical Reviews in Oncology/hematology·Angel MonteroCarmen Rubio
Mar 28, 2020·The Breast : Official Journal of the European Society of Mastology·Mausam PatelThomas Kim
Mar 10, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Simone Aparecida de Bessa GarciaRenata Freitas
Oct 24, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Sabrina Kahler-Ribeiro-FontanaViviana Galimberti
May 13, 2021·Seminars in Cancer Biology·Andrea R Lim, Cyrus M Ghajar
May 28, 2021·The American Journal of Pathology·Samir JanaDennis Jones

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