Long-term cancer risk after hysterectomy on benign indications: Population-based cohort study

International Journal of Cancer. Journal International Du Cancer
Daniel AltmanHenrik Falconer

Abstract

Hysterectomy on benign indications is associated with an increased risk for adverse health effects. However, little is known about the association between hysterectomy and subsequent cancer occurrence later in life. The purpose of this study was to assess the effect of hysterectomy on the incidence of cancer. In this population-based cohort study, we used data on 111,595 hysterectomized and 537,9843 nonhysterectomized women from nationwide Swedish Health Care registers including the Inpatient Register, the Cancer Register and the Cause of Death Register between 1973 and 2009. Hysterectomy with or without concomitant bilateral salpingo-ophorectomy (BSO) performed on benign indications was considered as exposure and incidence of primary cancers was used as outcome measure. Rare primary cancers (<100 cases for the two groups combined) were excluded from analysis. A marginal risk reduction for any cancer was observed for women with previous hysterectomy and for those with hysterectomy and concurrent BSO (HR 0.93, 95% CI 0.91-0.95 and HR 0.92, 95% CI 0.87-0.96, respectively). Compared to nonhysterectomized women, significant risks were observed for thyroid cancer (HR 1.76, 95% CI 1.45-2.14). For both hysterectomy and hysterectomy wi...Continue Reading

References

May 1, 1992·British Journal of Obstetrics and Gynaecology·M P VesseyD Yeates
Jan 1, 1983·Journal of Neuro-oncology·M PoissonD Philibert
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·I Jung-Testas, E E Baulieu
Jan 30, 2002·Obstetrics and Gynecology·Cynthia M Farquhar, Claudia A Steiner
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Riitta LuotoEero Pukkala
Feb 14, 2003·Lancet·Steven I Sherman
May 12, 2004·Lancet·Ian R WhittleDonald Collie
May 15, 2004·Thyroid : Official Journal of the American Thyroid Association·Geoffrey P Redmond
Jun 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Cynthia M FarquharAlistair W Stewart
Apr 4, 2006·American Journal of Obstetrics and Gynecology·Abraham N MorseBarbara P Yawn
Jul 22, 2006·Climacteric : the Journal of the International Menopause Society·Hu XiangyingShi Yifu
Nov 6, 2007·Obstetrics and Gynecology·Jennifer M WuAnthony G Visco
Mar 4, 2008·Obstetrics and Gynecology·Tommaso Falcone, Mark D Walters
Mar 22, 2008·American Journal of Obstetrics and Gynecology·Daniel AltmanFredrik Granath
Jan 14, 2009·Acta Obstetricia Et Gynecologica Scandinavica·Cecilia LundholmDaniel Altman
Aug 27, 2010·Current Opinion in Obstetrics & Gynecology·Catharina Forsgren, Daniel Altman
Dec 15, 2010·Archives of Internal Medicine·Daniel AltmanHenrik Grönberg
Oct 24, 2012·Cancer Causes & Control : CCC·Geoffrey C KabatThomas E Rohan
Oct 22, 2013·Cancer Epidemiology·Lene AndersenDavid Gaist
May 16, 2014·Menopause : the Journal of the North American Menopause Society·Iffat RahmanAlicja Wolk
Jul 22, 2014·International Journal of Cancer. Journal International Du Cancer·Raul Zamora-RosSilvia Franceschi
Jan 30, 2015·Journal of the National Cancer Institute·Henrik FalconerDaniel Altman

❮ Previous
Next ❯

Citations

Jan 20, 2017·International Journal of Cancer. Journal International Du Cancer·Henrik FalconerDaniel Altman
Aug 22, 2018·Obstetrics and Gynecology·Shannon K Laughlin-Tommaso, Elizabeth A Stewart
Aug 2, 2017·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Rebecca C RamdhanR Shane Tubbs
Apr 4, 2021·Cancer Epidemiology·Sabbir T RahmanSusan J Jordan
Feb 24, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Louise F WilsonSusan J Jordan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.