Long-term carcinogenicity study in Syrian golden hamster of particulate emissions from coal- and oil-fired power plants

Environmental Health Perspectives
S A PerssonF Bergman

Abstract

Male Syrian golden hamsters were given 15 weekly intratracheal instillations with suspensions of coal fly ash or oil fly ash. Controls were instilled with saline containing gelatine (0.5 g/100 mL) or to check particle effects with suspensions of hematite (Fe2O3). The common weekly dose was 4.5 mg/hamster. In addition, one subgroup of hamsters was treated with oil fly ash at a weekly dose of 3.0 mg/hamster and another with coal fly ash at a weekly dose of 6.0 mg/hamster. Other groups of hamsters were treated with suspensions of benzo[a]pyrene (BaP) or with suspensions on coal fly ash, oil fly ash, or Fe2O3 coated with BaP. The mass median aerodynamic diameters of the coal and oil fly ashes were 4.4 microns and 28 microns, respectively. Hamsters treated with oil fly ash showed a higher frequency of bronchiolar-alveolar hyperplasia than hamsters in the other treatment groups. Squamous dysplasia and squamous metaplasia were most frequent in animals treated with suspensions of BaP or BaP-coated particles. The earliest appearance of a tumor, the highest incidence of tumors, and the highest incidence of malignant tumors were observed in hamsters treated with oil fly ash coated with BaP. Squamous cell carcinoma and adenosquamous carcin...Continue Reading

References

Jan 1, 1987·Experimental Lung Research·M SvartengrenP Camner
Oct 1, 1982·Journal of Toxicology and Environmental Health·C I WeiC E Chrisp
Mar 30, 1984·Toxicology and Applied Pharmacology·J D SunR O McClellan
Aug 1, 1984·Environmental Research·L J Schiff, J A Graham
Jan 1, 1983·Environmental Health Perspectives·M AhlbergB Steen
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·P NettesheimR Jamasbi
Jan 1, 1980·Bulletin of Mathematical Biology·M Schum, H C Yeh
Jan 1, 1980·Bulletin of Mathematical Biology·H C Yeh, G M Schum
Jan 1, 1965·Journal of the Air Pollution Control Association·U SAFFIOTTIP SHUBIK

❮ Previous
Next ❯

Citations

Feb 1, 1997·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·S RittinghausenU Mohr
Jan 27, 2009·Mutation Research·Flavio Manoel Rodrigues da Silva Júnior, Vera Maria Ferrão Vargas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.