Long-term cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients

Clinical Endocrinology
G JohannssonK Caidahl

Abstract

The long-term cardiovascular effects of GH administration in adults are of major clinical importance, given the increasing use of such treatment. We have evaluated long-term cardiovascular effects of recombinant human GH (rhGH) substitution in GH deficient men. S.c. rhGH 0.5 U/kg/week or placebo was administered in a 6-month double-blind, cross-over study, followed (after a year without substitution) by a 42-month period of open GH substitution. We evaluated 7 GH-deficient men serially and compared the results with 21 men matched in terms of age and height. Investigations included exercise tests and Doppler-echocardiography to determine exercise capacity and cardiovascular performance. Heart rate and systolic blood pressure at rest increased with GH substitution to the level of the controls, as did diastolic blood pressure after an initial reduction. Age-adjusted exercise capacity increased during the study and we found no evidence of ischaemic heart disease on exercise ECG. Stroke volume increased with GH substitution, thereby normalizing the initially reduced cardiac index. There was no significant change in left atrial or ventricular internal dimensions, systolic function as measured by fractional shortening, or diastolic fu...Continue Reading

Citations

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