Long-Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer

Journal of the American Heart Association
Yun-Jiu ChengSu-Hua Wu

Abstract

Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of heart disease is uncertain. We performed a meta-analysis to investigate the link between radiotherapy and long-term cardiovascular morbidity and mortality in patients with breast cancer. We performed a literature search using MEDLINE (January 1966 to January 2015) and EMBASE (January 1980 to January 2015) with no restrictions. Studies that reported relative risk (RR) estimates with 95%CIs for the associations of interest were included. Pooled effect estimates were obtained by using random-effects meta-analysis. Thirty-nine studies involving 1 191 371 participants were identified. Patients who received left-sided radiotherapy, as compared with those receiving right-sided radiotherapy, experienced increased risks of developing coronary heart disease (RR 1.29, 95%CI 1.13-1.48), cardiac death (RR 1.22, 95%CI 1.08-1.37) and death from any cause (RR 1.05, 95%CI 1.01-1.10). In a comparison of patients with radiotherapy and without radiotherapy, the RRs were 1.30 (95%CI 1.13-1.49) for coronary heart disease and 1.38 (95%CI 1.18-1.62) for cardiac mortality. Radiotherapy for brea...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L E RutqvistH Johansson
May 1, 1986·International Journal of Radiation Oncology, Biology, Physics·H HøstM Loeb
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J CuzickH Host
Mar 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P ValagussaG Bonadonna
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J NixonJ R Harris
Oct 23, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G GyenesT Fornander
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·L F PaszatE Holowaty
Mar 10, 2001·International Journal of Radiation Oncology, Biology, Physics·P H HardenberghL B Marks
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine A VallisAndreas Wielgosz
Jun 1, 2002·JAMA : the Journal of the American Medical Association·Karin Huwiler-MüntenerMatthias Egger
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Wendy A WoodwardThomas A Buchholz
Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Zhanat A CarrKiyohiko Mabuchi
Mar 17, 2005·Journal of the National Cancer Institute·Sharon H GiordanoJames S Goodwin
Apr 21, 2005·British Journal of Cancer·A M GeigerL Bernstein
Feb 1, 2006·International Journal of Radiation Oncology, Biology, Physics·Maartje J HooningFlora E van Leeuwen
Aug 16, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleanor E R HarrisLawrence J Solin
Mar 6, 2007·International Journal of Radiation Oncology, Biology, Physics·John J DoyleDawn Hershman
Mar 8, 2007·Journal of the National Cancer Institute·Maartje J HooningFlora E van Leeuwen
Jul 4, 2007·International Journal of Radiation Oncology, Biology, Physics·Jacques H BorgerFlora E van Leeuwen
Jul 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Candace R CorreaEleanor E Harris
Sep 4, 2007·Cancer Treatment Reviews·Elzbieta Senkus-Konefka, Jacek Jassem
Nov 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Carolyn W TaylorSarah C Darby
Apr 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Carolyn W TaylorSarah C Darby
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michele Y HalyardEdith A Perez
Aug 26, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BouchardyV Vinh-Hung
Sep 17, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lucas CaussaMarc A Bollet
Jan 22, 2011·Journal of the American College of Cardiology·Kim BouillonFlorent de Vathaire
Jul 15, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Paul McGaleMarianne Ewertz
Oct 20, 2011·Journal of Medical Imaging and Radiation Oncology·Wei WangJohn Boyages
Mar 15, 2013·The New England Journal of Medicine·Sarah C DarbyPer Hall

❮ Previous
Next ❯

Citations

Mar 2, 2018·Expert Opinion on Pharmacotherapy·Nathalie DonisPatrizio Lancellotti
Mar 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Marcelo F BenvenisteEdith M Marom
Feb 14, 2019·The International Journal of Cardiovascular Imaging·Dinu Valentin BalanescuCezar Iliescu
Jun 5, 2019·Current Treatment Options in Cardiovascular Medicine·Katherine Lee ChuyDipti Gupta
Jan 24, 2020·Journal of Cardiac Surgery·Onur B DolmaciAbdullah Kaya
Aug 19, 2020·European Journal of Heart Failure·José Luis ZamoranoGiorgio Minotti
Nov 10, 2018·Cardiology Research and Practice·Christopher DeZorzi
Nov 2, 2019·Health Science Reports·Chelsea R StoneChristine M Friedenreich
Jul 25, 2018·Frontiers in Cardiovascular Medicine·Kareena M MenezesPremkumar B Saganti
May 11, 2019·Current Treatment Options in Oncology·Katherine Lee Chuy, Anthony F Yu
May 8, 2018·Breast Cancer Research and Treatment·C WadstenM Sund
Aug 11, 2017·Japanese Journal of Radiology·Nadeem M S NagiAhmed M E Abdalla
May 12, 2020·The Breast Journal·Michael D Lagios
Jan 8, 2020·International Journal of Molecular Sciences·Francis Boateng, Wilfred Ngwa
Nov 20, 2019·Current Atherosclerosis Reports·Rose Mary Ferreira Lisboa da Silva
May 14, 2020·BMC Cancer·Benoîte MeryLaurent Bertoletti
Jun 11, 2020·Journal of Cardiovascular Medicine·Irma BiscegliaUNKNOWN on the behalf of ANMCO Cardio-Oncology Task Force
Nov 25, 2020·Radiation Oncology Journal·Cecil M Benitez, Susan J Knox
Jan 4, 2021·Cellular and Molecular Life Sciences : CMLS·Raghda RamadanLuc Leybaert
Jan 6, 2021·Environment International·Stefania PapatheodorouPetros Koutrakis
Feb 7, 2020·American Journal of Clinical Oncology·Helen A ShihAlan C Hartford
Feb 9, 2021·Frontiers in Cardiovascular Medicine·Nachiket AptePaari Dominic
Jan 3, 2019·Journal of Occupational and Environmental Medicine·Vanessa J M Al RashidaAkshay Sood
Mar 23, 2021·Journal of the American Heart Association·Siddharth J TrivediLiza Thomas
Mar 25, 2019·Bulletin du cancer·Emmanuel KammererJuliette Thariat
May 1, 2021·Cancers·Ana Aurora Díaz-GavelaTeresa López-Fernández
Aug 2, 2021·International Journal of Cardiology·Andrija MateticMamas A Mamas
Aug 28, 2021·Journal of Personalized Medicine·Anna BurguinFrancine Durocher

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American College of Cardiology
Yun-Jiu ChengSu-Hua Wu
Journal of the American Heart Association
Yun-Jiu ChengSu-Hua Wu
Journal of the National Cancer Institute
Sharon H GiordanoJames S Goodwin
© 2022 Meta ULC. All rights reserved