Long-Term Carriage of Ciprofloxacin-Resistant Escherichia coli Isolates in High-Risk Nursing Home Residents

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Miriam D IsmailBetsy Foxman

Abstract

BACKGROUND Rates of multidrug-resistant gram-negative organisms are surpassing those of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci in nursing homes (NHs). OBJECTIVE To characterize the incidence and duration of carriage of ciprofloxacin-resistant Escherichia coli (CipREc) in NHs and identify those in the O25b-ST131 lineage. METHODS We collected 227 CipREc isolates obtained by routine and regular surveillance of high-risk NH residents with indwelling devices. Repetitive element palindromic (REP)-polymerase chain reaction assay and multiplex polymerase chain reaction amplification for O25b-ST131 E. coli detection were performed using (GTG)5-primers and O25pabBspe and trpA2 primer pairs, respectively. RESULTS We found a high period prevalence of CipREc colonization (21.5%), high rates of recolonization with the same strain following clearing (0.46 recolonizations/ person/ year), and an acquisition incidence of 1.05 cases/1,000 person-days. Almost three-quarters of colonized residents carried strains in the O25b-ST131 E. coli lineage. Compared with isolates not in the lineage, O25b-ST131 isolates were carried significantly longer (10 vs 3 months). We identified 18 different REP-types; 2 occurre...Continue Reading

Associated Clinical Trials

Feb 4, 2010·Lona Mody, Lona Mody

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Citations

Jul 29, 2016·Frontiers in Cellular and Infection Microbiology·Betina Hebbelstrup JensenKaren A Krogfelt
Oct 21, 2016·Intensive Care Medicine·Jean-François TimsitMatteo Bassetti
Sep 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Joyce WangEvan S Snitkin
Jul 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Veronika L TchesnokovaEvgeni V Sokurenko

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