Long-term catamnesis on the topic of uses and side effects of lithium prevention of phasic psychoses

Fortschritte der Neurologie-Psychiatrie
H Koufen, U Consbruch

Abstract

A lithium long-term catamnesis of 124 patients (107 manic-depressive and 17 schizoaffective psychoses) after more than 8 years of lithium prophylaxis led to the following results: 1.) Recovering: 30.3%. Improvement - particularly mitigation of the episodes of illness -: 56%. Lack of efficiency: 13%. Mean incidence of episodes of illness before lithium 0.57 per year, during lithium 0.36. Mean incidence of hospitalisation before lithium 3.4 years, during Lithium 7.1 years. Deterioration following discontinuation of lithium: 21 of 22 cases. 2.) Side effects at the beginning: 61.2%, finally 42.7% (incidence of struma 19.5% of tremor 19%, of polydipsia/polyuria 9.1%). 3.) EEG changes (general slowing-down and dysrhythmia, to a quarter focally accentuated): 59%. 4.) Normal results of haematologic and clinical-chemical investigations (28 parameter) except serum creatinine (10%), creatinine clearance (20.5%) and leucocytosis (13%). The authors discuss the reduced incidence of recovery and the quantity of side effects based on the aspect of long-term catamnesis. Further studies are necessary with regard to the selection of lithium-treated patients, to the duration of prophylaxis without efficiency and to the shift from initial efficienc...Continue Reading

Citations

Aug 1, 1992·Journal of Affective Disorders·B Müller-OerlinghausenJ Volk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

European Archives of Psychiatry and Neurological Sciences
F BürkH J Möller
Archives of General Psychiatry
L TräskmanL Sjöstrand
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
D Marazziti, L Conti
© 2022 Meta ULC. All rights reserved