Long-Term Change in Cardiorespiratory Fitness in Relation to Atrial Fibrillation and Heart Failure (from the Kuopio Ischemic Heart Disease Risk Factor Study)

The American Journal of Cardiology
Hassan KhanJari A Laukkanen

Abstract

The benefits of aerobic fitness in relation to all-cause and cardiovascular mortality is well established; however, the associations of long-term change in cardiorespiratory fitness (CRF) with incident heart failure (HF) and atrial fibrillation (AF) have not been studied before. The Kuopio Ischaemic Heart Disease Risk Factor Study is a prospective cohort comprising men aged 42 to 60 years from the city of Kuopio and its surroundings, with a baseline examination between 1984 and 1989 (V1), a re-examination at 11 years (V2), and up to 15 years of follow-up from V2. CRF, as assessed by VO2max, was measured at both visits using respiratory gas exchange during maximal exercise tolerance test. The difference (ΔVO2max) was estimated as VO2max (V2) - VO2max (V1). Participants with no missing data on both baseline and 11-year exercise test were included (n = 481). The mean ΔVO2max was -5.4 ml/min⋅kg (standard deviation 5.4). During a median follow-up of 14.3 years (interquartile range 13.3 to 15.1), 46 incident HF (9.6%) and 73 incident AF (15.2%) events were recorded. In a multivariate analysis adjusted for baseline age, baseline VO2max, systolic blood pressure, smoking, type 2 diabetes, and cardiovascular disease, per 1 ml/min⋅kg high...Continue Reading

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Citations

Feb 28, 2019·European Journal of Heart Failure·Setor K Kunutsor, Jari A Laukkanen
Jun 28, 2019·Medicine and Science in Sports and Exercise·Lars E GarnvikBjarne M Nes
Dec 25, 2019·Scandinavian Journal of Medicine & Science in Sports·Jani P VaaraHeikki Kyröläinen
Oct 28, 2019·Heart Failure Reviews·Zhengbiao XueWengen Zhu
Jul 25, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Paul R AfolabiChristopher D Byrne
Oct 29, 2020·Arquivos brasileiros de cardiologia·Jari A Laukkanen, Setor K Kunutsor
Mar 30, 2021·Mayo Clinic Proceedings·Jari A LaukkanenSetor K Kunutsor

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