Long-term changes in entorhinal-dentate evoked potentials induced by electroconvulsive shock seizures in rats

Brain Research
W M BurnhamR J Racine

Abstract

Entorhinal-dentate evoked potentials were measured in rats before and after: (1) eight electroconvulsive shock (ECS) seizures, or (2) matched handling. In animals that received ECS, evoked potentials were significantly enhanced, as evidenced by a long-lasting increase in the amplitude of the population spike. This increase in population-spike amplitude lasted for at least 3 months after the last ECS trial. No evoked-potential changes were observed in the subjects that received matched handling. These data suggest that ECS seizures produce long-lasting, perhaps permanent, changes in the brain.

References

Sep 1, 1975·Electroencephalography and Clinical Neurophysiology·R RacineW M Burnham
Nov 1, 1991·Archives of General Psychiatry·C E CoffeyW E Wilkinson
Aug 16, 1991·Brain Research·R J RacineC Evans
Feb 6, 1988·Lancet·A J RamptonC S Stuart
Jan 1, 1986·Annals of the New York Academy of Sciences·B S Meldrum
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Dec 30, 1985·Brain Research·R D Russell, J S Stripling
Nov 27, 1972·Brain Research·R J RacineW M Burnham
Feb 7, 1983·Brain Research·R J RacineS Hafner
May 13, 1994·Brain Research. Developmental Brain Research·B L TrommerJ J Kennelly

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Citations

Sep 7, 2000·Neuroscience and Biobehavioral Reviews·H E EdwardsW M Burnham
Oct 31, 1998·Brain Research. Molecular Brain Research·C J WatkinsN R Newberry
Sep 20, 2000·Experimental Neurology·B W ScottW M Burnham
Mar 28, 2020·The International Journal of Neuropsychopharmacology·Fenghua ChenJens R Nyengaard
Jan 8, 2003·Clinical EEG (electroencephalography)·Fumio KubotaKazuo Takeuchi

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