Long-term changes in retinal vascular diameter and cognitive impairment in type 1 diabetes

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Karen A NunleyCaterina Rosano

Abstract

To assess associations between cognitive impairment and longitudinal changes in retinal microvasculature, over 18 years, in adults with type 1 diabetes. Participants of the Pittsburgh Epidemiology of Diabetes Complications Study received ≥3 fundus photographs between baseline (1986-1988) and time of cognitive assessment (2010-2015: N = 119; 52% male; mean age and type 1 diabetes duration 43 and 34 years, respectively). Central retinal arteriolar equivalent and central retinal venular equivalent were estimated via computer-based methods; overall magnitude and speed of narrowing were quantified as cumulative average and slope, respectively. Median regression models estimated associations of central retinal arteriolar equivalent and central retinal venular equivalent measures with cognitive impairment status, adjusted for type 1 diabetes duration. Interactions with HbA1c, proliferative retinopathy and white matter hyperintensities were assessed. Compared with participants without cognitive impairment, those with clinically relevant cognitive impairment experienced 1.8% greater and 31.1% faster central retinal arteriolar equivalent narrowing during prior years (t = -2.93, p = 0.004 and t = -3.97, p < 0.0001, respectively). Interact...Continue Reading

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Citations

Dec 6, 2018·Current Opinion in Neurology·Stefanie J Rodenbeck, Devin D Mackay
Sep 29, 2018·Journal of Experimental Neuroscience·Oana M Dumitrascu, Touseef A Qureshi

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