Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration.

Neuroscience
Peter U HámorMarek Schwendt

Abstract

The central nucleus of the amygdala (CeA) is a striatum-like structure that contains mainly inhibitory circuits controlling a repertoire of (mal)adaptive behaviors related to pain, anxiety, motivation, and addiction. Neural activity in the CeA is also necessary for the expression of persistent and robust drug seeking, also termed 'incubation of drug craving.' However, neuroadaptations within this brain region supporting incubated drug craving have not been characterized. Here, we conducted a comprehensive analysis of protein expression in the CeA of male rats after prolonged (45-day) abstinence from extended-access cocaine self-administration using a quantitative proteomic approach. The proteomic analysis identified 228 unique proteins altered in cocaine rats relative to animals that received saline. Out of the identified proteins, 160 were downregulated, while 68 upregulated. Upregulation of tyrosine hydroxylase and downregulation of neural cell-adhesion protein contactin-1 were validated by immunoblotting. Follow-up analysis by the Ingenuity Pathway Analysis tool revealed alterations in protein networks associated with several neurobehavioral disorders, cellular function and morphology, as well as axogenesis, long-term potent...Continue Reading

References

Aug 1, 1978·The Journal of Comparative Neurology·J H FallonR Y Moore
Jan 1, 1992·Annual Review of Neuroscience·M Davis
Jun 28, 1992·Annals of the New York Academy of Sciences·C P O'BrienR Ehrman
Jul 1, 1992·Synapse·N D VolkowL Handlesman
Feb 1, 1986·Archives of General Psychiatry·F H Gawin, H D Kleber
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Gallagher, P C Holland
Aug 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J M StapletonE D London
Apr 1, 1996·Current Opinion in Neurobiology·M Gallagher, A A Chiba
Feb 1, 1996·Neuron·S Maren, M S Fanselow
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·S GrantA Margolin
Jan 19, 1999·The American Journal of Psychiatry·A R ChildressC P O'Brien
Aug 3, 2000·Brain Research Bulletin·M S TodtenkopfJ R Stellar
Nov 4, 2000·The American Journal of Psychiatry·H GaravanE A Stein
Sep 7, 2001·Rapid Communications in Mass Spectrometry : RCM·K JanekE Krause
Mar 23, 2002·Protein Science : a Publication of the Protein Society·Kimberly A LeeJames B Hurley
Jul 3, 2002·Nature Reviews. Neuroscience·Mark G Baxter, Elisabeth A Murray
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Jul 5, 2003·Physiological Reviews·P SahJ Power
Nov 25, 2003·Analytical Chemistry·Alexey I NesvizhskiiRuedi Aebersold
May 25, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Volker NeugebauerJeong S Han
Mar 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·B Jill VentonR Mark Wightman
Nov 7, 2006·Trends in Neurosciences·Lin LuYavin Shaham
Apr 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fei DuWei Chen
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-Qin LiLin Lu

❮ Previous
Next ❯

Citations

Feb 25, 2021·The Biochemical Journal·Claire ThorntonRami Yaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

© 2022 Meta ULC. All rights reserved