Long-term changes in the molecular composition of the glial scar and progressive increase of serotoninergic fibre sprouting after hemisection of the mouse spinal cord

The European Journal of Neuroscience
Emeline CamandI Dusart

Abstract

The scarring process occurring after adult central nervous system injury and the subsequent increase in the expression of certain extracellular matrix molecules are known to contribute to the failure of axon regeneration. This study provides an immunohistochemical analysis of temporal changes (8 days to 1 year) in the cellular and molecular response of the Swiss mouse spinal cord to a dorsal hemisection and its correlation with the axonal growth properties of a descending pathway, the serotoninergic axons. In this lesion model, no cavity forms at the centre of the lesion. Instead, a dense fibronectin-positive tissue matrix occupies the centre of the lesion, surrounded by a glial scar mainly constituted by reactive astrocytes. NG2 proteoglycan and tenascin-C, potential axon growth inhibitors, are constantly associated with the central region. In the glial scar, tenascin-C is never observed and the expression of chondroitin sulphate proteoglycans (revealed with CS-56 and anti-NG2 antibodies) highly increases in the week following injury to progressively return to their control level. In parallel, there is an increasing expression of the polysialilated neural cell adhesion molecule by reactive astrocytes. These molecular changes a...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E D LaywellD A Steindler
Apr 1, 1987·Journal of Neurocytology·W J Streit, G W Kreutzberg
Jan 1, 1983·Acta neurochirurgica. Supplementum·M BerryG H Thomas
May 1, 1994·The European Journal of Neuroscience·I Dusart, M E Schwab
Oct 1, 1995·Current Opinion in Neurobiology·I AubertF H Gage
Jan 7, 1998·Trends in Neurosciences·J L RidetF H Gage
Feb 11, 2000·Annals of the New York Academy of Sciences·L GuthO Steward
Apr 12, 2002·Nature·Elizabeth J BradburyStephen B McMahon
Apr 30, 2003·Neuron·Ji Eun KimStephen M Strittmatter
Apr 30, 2003·Neuron·Binhai ZhengMarc Tessier-Lavigne
Jun 10, 2003·The Journal of Comparative Neurology·Julie M SrogaPhillip G Popovich

❮ Previous
Next ❯

Citations

Mar 1, 2012·Cell and Tissue Research·Hitoshi KawanoGeoffrey Raisman
Mar 16, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Akshata AlmadDana M McTigue
Jun 7, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yi ZhangXuenong Bo
Mar 23, 2007·Journal of Neurotrauma·Shuxin ZhangEric G Holmberg
Apr 25, 2006·Journal of Neurotrauma·Theo Hagg, Martin Oudega
Jul 9, 2011·Science·Christian GöritzJonas Frisén
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robin E WhiteLyn B Jakeman
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia L HawthorneJerry Silver
Sep 3, 2011·Surgical Neurology International·Manoel Baldoino Leal-Filho
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Abderrahman El MaaroufUrs Rutishauser
Jul 25, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ricco LindnerSimone Di Giovanni
Sep 10, 2014·Journal of the Neurological Sciences·Mitsuru HanadaYukihiro Matsuyama
Jul 15, 2009·Journal of Neuroscience Research·Marit N MelandChristopher S Stipp
Jul 6, 2010·Brain Research·Suelen Adriani MarquesAna Maria Blanco Martinez
Mar 12, 2016·Trends in Neurosciences·David KremerPatrick Küry
May 17, 2008·Experimental Neurology·Jaivijay RamuPonnada Narayana
Jun 2, 2015·Experimental Neurology·Stefan Wiese, Andreas Faissner
Mar 17, 2007·Molecular and Cellular Neurosciences·Yi ZhangXuenong Bo
Nov 3, 2005·The European Journal of Neuroscience·Rosine WehrleIsabelle Dusart
Jul 12, 2008·Glia·Ina B WannerJohn L Bixby
Oct 24, 2007·Biochemical and Biophysical Research Communications·Noriko HayashiAkio Wanaka
Oct 13, 2006·Progress in Neurobiology·Luca Bonfanti
Apr 29, 2015·Organogenesis·Andrew M HandorfWan-Ju Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.