PMID: 2122331Jul 31, 1990Paper

Long-term changes of synaptic transmission induced by arachidonic acid in the CA1 subfield of the rat hippocampus

Neuroscience Letters
C DrapeauM Avoli

Abstract

The effects induced by arachidonic acid upon excitatory synaptic transmission were investigated in the CA1 subfield of rat hippocampal slices. Perfusion with medium containing 50 microM of arachidonic acid induced in 12 of 19 experiments a long-lasting potentiation of the stratum radiatum-induced responses recorded in the cell body and in the apical dendritic layers. In 5 of 19 experiments, arachidonic acid evoked a depression of the same responses. Both effects were antagonized by nordihydroguaiaretic acid which is an inhibitor of lipoxygenase enzymes. These results demonstrate that one or more than one of the arachidonic acid metabolites of the lipoxygenase pathways might be involved in the long-term modulation of synaptic transmission in the hippocampus.

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Citations

Sep 1, 1991·Neurochemical Research·L Pellerin, L S Wolfe
Aug 1, 1995·Progress in Neurobiology·H Katsuki, S Okuda
Apr 13, 1992·Neuroscience Letters·S Radpour, A M Thomson
Jun 1, 1991·Current Opinion in Neurobiology·S A Siegelbaum, E R Kandel
Jun 1, 1992·Current Opinion in Neurobiology·Z I Bashir, G L Collingridge
Jan 24, 2004·Brain Research. Brain Research Reviews·John W Phillis, Michael H O'Regan
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Jun 19, 1998·Brain Research. Molecular Brain Research·T NishizakiK Sumikawa
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Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T J O'DellO Arancio
Jun 1, 1995·The European Journal of Neuroscience·C Hölscher
Oct 12, 2013·Molecular Neurobiology·Tatsurou YagamiHiromi Koma
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Geert M J Ramakers, Johan F Storm
Nov 12, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vanessa de Jesus De-PaulaOrestes Vicente Forlenza
Sep 15, 2016·Journal of Experimental Neuroscience·Thiago Fernando BeckhauserRoberto De Pasquale
Mar 6, 2002·The Journal of Biological Chemistry·Kaori KashiwagiNaoaki Saito

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