Long-term chemotherapy of HIV-associated Kaposi's sarcoma with liposomal doxorubicin

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Ulrich HenggeM Goos

Abstract

The aim of this study was to examine the outcome, adverse events and clinical complications of long-term chemotherapy with pegylated liposomal doxorubicin (PegLiposomal DOX) for human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS) in the pre-highly active antiretroviral therapy (HAART) era. A phase II study over a 4-year period in a tertiary care university hospital was carried out. 52 acquired immunodeficiency syndrome (AIDS)-patients with advanced KS received long-term chemotherapy (71+/-51 weeks) with a mean of 22.8+/-18.2 cycles and a mean cumulative liposomal doxorubicin dose of 456+/-364 mg/m(2) (120-1040 mg/m(2)). Tumour burden, duration and dosage of PegLiposomal DOX, adverse events, opportunistic infections, immunological parameters and HIV load were measured. A complete (10%) or partial response (56%) was achieved while on chemotherapy. 10 patients (19%) showed stable disease. Tumour progression was observed in 8 patients (15%). Importantly, chemotherapy with PegLiposomal DOX was also successful after previous cytostatic therapy with bleomycin and vincristine. The most common adverse events included leucopenia, neutropenia, anaemia, and increased liver function tests. 34 patients (65%) developed new opp...Continue Reading

References

May 1, 1986·Journal of Clinical Pathology·N D FrancisA W Boylston
Feb 6, 1993·Lancet·U R HenggeM Goos
Aug 21, 1993·Lancet·U R HenggeM Goos
Sep 19, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·A GabizonY Barenholz
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M CattelanL Chieco-Bianchi

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Citations

Aug 10, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Marini, U R Hengge
Sep 21, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Mutlu DoganFikri Icli
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fakhrul AhsanAna I Torres Suarez
Aug 25, 2007·Nanomedicine·David B Resnik, Sally S Tinkle
Sep 1, 2007·Women's Health·M ShehataS Chan
Sep 24, 2009·Biologics : Targets & Therapy·Francesca Cainelli, Alfredo Vallone
May 18, 2004·International Journal of Cancer. Journal International Du Cancer·Carlo LeonettiGabriella Zupi
Mar 15, 2005·Anesthesiology Clinics of North America·J Lee White, Marcel E Durieux
Oct 29, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·X-J WuJ Mijit
Dec 17, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lakshmi Narashimhan RamanaUma Maheswari Krishnan
Feb 15, 2002·Clinical Journal of Oncology Nursing·Kathy Wilkinson
Jul 4, 2008·International Journal of STD & AIDS·A MosamH M Coovadia
Jan 13, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J DelyonC Lebbé
Jul 26, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mothanje Barbara LuciaRoberto Cauda
Jul 13, 2006·International Journal of Immunopathology and Pharmacology·R Di TrolioS De Placido
Sep 14, 2007·The Journal of Dermatological Treatment·Iria CastiñeirasEduardo Fonseca
Nov 5, 2017·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R-E KlingenbergUNKNOWN Kompetenznetz HIV/AIDS

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