Long-term clinical and radiological assessment of untreated severe cartilage damage in the knee: a natural history study

Scandinavian Journal of Medicine & Science in Sports
Wojciech WiduchowskiBogdan Koczy

Abstract

We aimed to evaluate whether and to what extent an isolated deep cartilage lesion localized within the tibiofemoral and the patellofemoral joint has an impact on the clinical outcomes and osteoarthritis (OA) progression when it is left untreated. From 1991 to 1994, 4121 consecutive knee arthroscopies were performed, and 37 of them in patients with a single isolated chondral lesion of Outerbridge grade 4 located within weight-bearing areas of the femoral and tibial condyles (FT group) and patella (P group). The lesion size ranged from 2 to 4 cm(2) . Outcomes were reported at a mean 15.3-year follow-up using the Lysholm score, the Tegner activity scale and the Womac score. The mean Lysholm, Tegner and Womac score in the FT group was 87.7, 5.6 and 88.7, respectively. In the P group, it was 83.8, 4.8 and 84.6, respectively (P<0.0.5). Osteoarthritic changes were found in 39% of the patients. There was no difference in OA severity between an injured and an uninjured knee. In patients of the FT group, there was a relationship between the incidence of tibiofemoral OA and patellofemoral OA (P=0.00075). Severe isolated single chondral damage left with no treatment has a limited influence on clinical outcomes and the development of OA.

References

Nov 1, 1989·The American Journal of Sports Medicine·K Sommerlath
Apr 1, 1988·Archives of Toxicology·K FentG Zbinden
Sep 1, 1985·Clinical Orthopaedics and Related Research·Y Tegner, J Lysholm
May 1, 1982·The American Journal of Sports Medicine·J Lysholm, J Gillquist
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Jul 18, 2000·Scandinavian Journal of Medicine & Science in Sports·J P ArokoskiH J Helminen
Jul 27, 2001·Osteoarthritis and Cartilage·T L BoegårdK Jonsson
Sep 15, 2001·Annals of the Rheumatic Diseases·F M CicuttiniS L Stuckey
May 2, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·J Richard SteadmanWilliam G Rodkey
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Nov 1, 1961·The Journal of Bone and Joint Surgery. British Volume·R E OUTERBRIDGE
Feb 3, 2004·The American Journal of Sports Medicine·Asbjørn ArøenLars Engebretsen
Apr 22, 2005·Annals of the Rheumatic Diseases·M Englund, L S Lohmander
Apr 13, 2007·The Knee·W WiduchowskiT Trzaska
Aug 19, 2007·Osteoarthritis and Cartilage·M L Davies-TuckF M Cicuttini
May 28, 2008·Injury·M R SteinwachsP C Kreuz
Feb 24, 2009·Arthritis Research & Therapy·David T Felson
Apr 2, 2009·Scandinavian Journal of Medicine & Science in Sports·Heikki J Helminen

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Citations

Aug 9, 2011·British Medical Bulletin·Asbjørn Arøen
Dec 17, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Andras HeijinkC Niek Van Dijk
Feb 7, 2012·The Journal of Knee Surgery·Christian Lattermann, Matthew R Luckett
Nov 17, 2015·International Journal of Molecular Sciences·Alessandro R ZorziJoão B Miranda
Jun 19, 2013·Clinics in Sports Medicine·Robert A Gallo, Timothy J Mosher
Apr 9, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Diego Costa AsturMoisés Cohen
Jul 16, 2010·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Kurt C HirshornScott Gillogly
Sep 11, 2013·Osteoarthritis and Cartilage·B MollonJ Theodoropoulos
Oct 28, 2016·International Journal of Rheumatic Diseases·Ved ChaturvediPatrick D W Kiely
Apr 10, 2014·The American Journal of Sports Medicine·Daniel SarisUNKNOWN SUMMIT study group
Oct 27, 2018·Orthopaedic Journal of Sports Medicine·Darby A HouckJonathan T Bravman
Sep 11, 2021·The Journal of Knee Surgery·Jorge ChahlaJack Farr

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