Long-term clinical and real-world experience with pirfenidone in the treatment of idiopathic pulmonary fibrosis

European Respiratory Review : an Official Journal of the European Respiratory Society
Vincent Cottin, T M Maher

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible, progressively destructive lung disease that culminates in respiratory failure and death. Randomised controlled trials have demonstrated that treatment of IPF patients with pirfenidone reduces lung function decline, improves progression-free survival and significantly reduces the risk of all-cause mortality at 1 year. Pirfenidone has been shown to have a favourable safety profile and was generally well tolerated over the long term in clinical trials and real-world experience. However, side-effect management is critical to help some patients remain on treatment over the long term. The primary treatment-related adverse events associated with pirfenidone therapy are gastrointestinal upset, rash and photosensitivity. Gastrointestinal events may be mitigated by ensuring that pirfenidone is taken with food, while skin symptoms may be reduced by avoiding sun exposure and frequent use of sunblock. Educating patients about the potential for these adverse events to occur and providing instructions prior to treatment to avoid adverse drug reactions are an important means of ensuring patients may derive the important benefits provided by long-term treatment with pirfenidone.

References

Dec 10, 2009·The European Respiratory Journal·H TaniguchiUNKNOWN Pirfenidone Clinical Study Group in Japan
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Brett LeyTalmadge E King
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
May 17, 2011·Lancet·Paul W NobleUNKNOWN CAPACITY Study Group
Jun 3, 2011·European Respiratory Review : an Official Journal of the European Respiratory Society·C J SchaeferK Kossen
Feb 21, 2013·Deutsche medizinische Wochenschrift·F BonellaU Costabel
Mar 19, 2014·Respiratory Investigation·Toru AraiSeiji Hayashi
May 20, 2014·The New England Journal of Medicine·Talmadge E KingUNKNOWN ASCEND Study Group
May 20, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Dominique ValeyreRoland M du Bois
Aug 15, 2014·Respiration; International Review of Thoracic Diseases·Ute OltmannsMichael Kreuter

❮ Previous
Next ❯

Citations

Feb 21, 2016·European Journal of Medicinal Chemistry·Danylo KaminskyyRoman Lesyk
Jul 19, 2015·The Lancet. Respiratory Medicine·Sara RoversiLeonardo M Fabbri
May 18, 2016·Scandinavian Journal of Gastroenterology·Sara-Irini KadirJens Kelsen
May 14, 2016·Expert Opinion on Drug Safety·Adam AndersonSteven D Nathan
Oct 21, 2016·Expert Opinion on Drug Safety·Sophie FletcherLuca Richeldi
Mar 8, 2017·Expert Review of Clinical Pharmacology·Peter M George, Athol U Wells
Mar 21, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jonathan A GalliGerard J Criner
Mar 16, 2017·Archivos de bronconeumología·Antoni XaubetJulio Ancochea
Sep 13, 2016·European Clinical Respiratory Journal·Goran Nadir SalihElisabeth Bendstrup
Sep 13, 2017·Respiration; International Review of Thoracic Diseases·Ulrich CostabelPaul W Noble
Jan 13, 2018·Frontiers in Medicine·Catharina C MoorMarlies S Wijsenbeek
Mar 8, 2018·Respiration; International Review of Thoracic Diseases·Demosthenes BourosUNKNOWN INDULGE IPF Study Group
Oct 5, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sally Ibbotson
Feb 8, 2018·Respiratory Research·Omar S UsmaniToby M Maher
Sep 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Sergio Harari, Antonella Caminati
Dec 8, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Lisa H LancasterUlrich Costabel
Feb 17, 2018·The European Respiratory Journal·Aurélien JustetRaphael Borie
Nov 18, 2018·The European Respiratory Journal·Luca RicheldiToby M Maher
Oct 18, 2018·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Clarice S MadrugaRonaldo R Laranjeira
Jun 11, 2019·Expert Review of Respiratory Medicine·Onofre Moran-MendozaIngrid Harle
Sep 13, 2019·International Journal of Mycobacteriology·Madhav H HandeS Arun
Jan 13, 2018·BMC Pulmonary Medicine·Iván Cherrez-OjedaAnnia Cherrez
Jul 15, 2015·Current Opinion in Pulmonary Medicine·Christopher S King, Steven D Nathan
Jul 17, 2018·Drugs & Therapy Perspectives : for Rational Drug Selection and Use·Katherine A Lyseng-Williamson
Apr 11, 2020·Journal of Clinical and Translational Hepatology·Cyriac Abby PhilipsPhilip Augustine
Dec 15, 2017·Frontiers in Medicine·Argyrios TzouvelekisDemosthenes Bouros
Jan 19, 2019·Investigative Ophthalmology & Visual Science·William M BerkowskiCaryn E Plummer
May 7, 2019·European Journal of Hospital Pharmacy. Science and Practice·Borja Marcos RibesTeresa Aznar
Apr 16, 2020·Respiratory Medicine Case Reports·Giulia CassoneAndreina Manfredi
Dec 24, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fateme PourgholamhosseinAli Mandegary
Apr 22, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Moez GhummanJyothi U Menon
Jan 20, 2021·Annals of the American Thoracic Society·Timothy M DempseyAndrew H Limper
Nov 14, 2015·Annual Review of Medicine·Anna S Selvaggio, Paul W Noble

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.