PMID: 8967878Dec 1, 1995Paper

Long-term clinical evaluation of an adsorbent column (BM-01) of direct hemoperfusion type for beta 2-microglobulin on the treatment of dialysis-related amyloidosis

Artificial Organs
Fumitake GejyoS Takata

Abstract

The clinical efficacy and safety of a beta 2-microglobulin (beta 2M) adsorbent column, BM-01, on the treatment of dialysis-related amyloidosis were investigated in 7 hemodialysis patients for more than 6 months. The percent reduction of serum beta 2M was more than 60-70%, and the level at the end of each session was less than 10 mg/L in almost all patients. The amount of beta 2M removed was calculated as more than 200-300 mg/session. The results demonstrated that BM-01 performed very well for removing beta 2M, was capable of maintaining less than 25 mg/L of time average concentration (TAC) for beta 2M, and improved the clinical symptoms. Clinically severe side effects were not observed. We recommend that BM-01 should undergo further evaluation for its usefulness in the long-term treatment of dialysis-related amyloidosis, though treatment with the column may not be successful in preventing the onset of the disease.

References

Jan 1, 1990·Contributions to Nephrology·F Gejyo, M Arakawa
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Jun 28, 1985·Biochemical and Biophysical Research Communications·F GejyoT Shirahama

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Citations

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F Gejyo
Sep 13, 2003·Kidney International·Takaya AbeSuhail Ahmad
Mar 18, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G A Siami, F S Siami
Dec 19, 2003·Advances in Renal Replacement Therapy·James F WinchesterNathan W Levin
Apr 24, 2009·Seminars in Dialysis·Arun V KrishnanMatthew C Kiernan
Jan 1, 1997·Ryōikibetsu shōkōgun shirīzu·F Gejyo
May 5, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·S FuruyoshiN Tani
Dec 19, 2003·Advances in Renal Replacement Therapy·William R Clark, James F Winchester
Aug 19, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kazuo SuzukiHidetoshi Kutsuki
Aug 5, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·J Kay, T Bardin
Jul 17, 2004·Therapeutic Drug Monitoring·Shuichi TsuruokaAkio Fujimura
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Christopher J DerryR Andrew Moore
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Douglas C McCrory, Rebecca N Gray
Mar 31, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yuzo WatanabeUNKNOWN “Maintenance Hemodialysis: Hemodialysis Prescriptions” Guideline Working Group, Japanese Society for Dialysis Therapy
Feb 24, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T KanekoY Katayama
Mar 27, 2001·Seminars in Dialysis·M I Jaradat, S M Moe
Feb 5, 2015·The International Journal of Artificial Organs·Marco SartoriClaudio Ronco
May 1, 1997·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·F GejyoM Arakawa
Jun 8, 2000·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·F Gejyo
Mar 27, 2001·Seminars in Dialysis·G A Ameer
Apr 1, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·V DavankovE Yousha
Dec 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L W Henderson
Apr 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L W Henderson

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