Abstract
To examine the 21 month clinical outcome and bleeding complications in hospital survivors with non-ST segment elevation acute coronary syndromes (NSTEACS) who were discharged with combined clopidogrel and aspirin anti-thrombotic therapy, and compare with those having ST segment elevation myocardial infarction (STEMI) who were discharged with aspirin alone. Observational study. A large university hospital. 224 patients were admitted to hospital with either NSTEACS or STEMI, and survived to discharge between 1 October 2001 and 31 December 2002. Cardiovascular death, total death, new myocardial infarction, unstable angina requiring hospitalisation, stroke or transient ischaemic attack, coronary revascularisation; and fatal, life threatening, major and minor bleeding over 21 months after discharge. Despite having no or small infarct (median maximum creatine kinase 155 v 1295 u/l; p<0.001) and taking more antianginal drugs, patients with NSTEACS had similar rates of cardiovascular death (9.5% v 8.3%; p = NS), new myocardial infarction (9.5% v 6.5%; p = NS) or unstable angina requiring hospitalisation (15.5% v 10.2%; p = NS) when compared with STEMI. Fatal, life threatening or major bleeding were <1% in both groups (p = NS); and mino...Continue Reading
References
Aug 23, 2000·European Heart Journal·J CollinsonR Mattu
Sep 15, 2000·Journal of the American College of Cardiology·J S AlpertJ P Bassand
Jan 13, 2001·Heart·UNKNOWN British Cardiac Society Guidelines and Medical Practice Committee and Royal College of Physicians Clinical Effectiveness and
Aug 25, 2001·The New England Journal of Medicine·S YusufUNKNOWN Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Jan 12, 2002·BMJ : British Medical Journal·UNKNOWN Antithrombotic Trialists' Collaboration
Sep 25, 2002·Circulation·Andrzej BudajUNKNOWN Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Trial Investigators
Oct 3, 2002·Circulation·Eugene BraunwaldUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of
Dec 31, 2002·European Heart Journal·Michel E BertrandUNKNOWN Task Force on the Management of Acute Coronary Syndromes of the European Society of Cardiology
Feb 1, 2003·European Heart Journal·Frans Van de WerfUNKNOWN Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology
Jul 28, 2004·Lancet·Hans-Christoph DienerUNKNOWN MATCH investigators
Aug 4, 2004·Circulation·Elliott M AntmanUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the
Aug 18, 2004·Heart·J S BirkheadUNKNOWN National Audit of Myocardial Infarction Project Steering Group
Nov 16, 2004·European Heart Journal·Anil K TanejaKeith A A Fox
Feb 16, 2005·Heart·K F CarruthersUNKNOWN GRACE Investigators
Mar 11, 2005·The New England Journal of Medicine·Marc S SabatineUNKNOWN CLARITY-TIMI 28 Investigators