Long term clinical outcome of chronic hepatitis C patients with sustained virological response to interferon monotherapy

Gut
Bart J VeldtSolko W Schalm

Abstract

The key end point for treatment efficacy in chronic hepatitis C is absence of detectable virus at six months after treatment. However, the incidence of clinical events during long term follow up of patients with sustained virological response is still poorly documented and may differ between the Eastern and Western world. To assess clinical end points during long term follow up of European patients with a sustained virological response to interferon monotherapy. Meta-analysis of individual patient data from eight European protocolled follow up studies of interferon treatment for chronic hepatitis C. A total of 286 sustained virological responders and 50 biochemical responders (detectable virus but normal alanine aminotransferase levels) were followed up for 59 months. Fifteen sustained virological responders (5.2%) had cirrhosis before treatment and 112 (39%) had genotype 1. The late virological relapse rate after five years of follow up was 4.7% (95% confidence interval (CI) 2.0-7.4) among sustained virological responders; all late relapses occurred within four years after treatment. Among sustained virological responders, the rate of decompensation after five years of follow up was 1.0% (95% CI 0.0-2.3) and none developed hep...Continue Reading

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