Long-Term Clinical Outcomes in a Cohort of Adults With Childhood-Onset Systemic Lupus Erythematosus

Arthritis & Rheumatology
N GrootS Kamphuis

Abstract

Childhood-onset systemic lupus erythematosus (SLE) is a severe, lifelong, multisystem autoimmune disease. Long-term outcome data are limited. This study was undertaken to identify clinical characteristics and health-related quality of life (HRQoL) of adults with childhood-onset SLE. Patients participated in a single study visit comprising a structured history and physical examination. Disease activity (scored using the SLE Disease Activity Index 2000 [SLEDAI-2K]), damage (scored using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and HRQoL (scored using the Short Form 36 Health Survey) were assessed. Medical records were reviewed. In total, 111 childhood-onset SLE patients were included; the median disease duration was 20 years, 91% of patients were female, and 72% were white. Disease activity was low (median SLEDAI-2K score 4), and 71% of patients received prednisone, hydroxychloroquine (HCQ), and/or other disease-modifying antirheumatic drugs. The vast majority of new childhood-onset SLE-related manifestations developed within 2 years of diagnosis. Damage such as myocardial infarctions began occurring after 5 years. Most patients (62%) experienced damage, predomin...Continue Reading

References

Nov 1, 1984·Journal of Clinical Psychology·A T Beck, R A Steer
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Aug 16, 2000·Arthritis and Rheumatism·A Zonana-NacachM Petri
Aug 12, 2003·Arthritis and Rheumatism·Angelo RavelliAlberto Martini
Jul 22, 2005·Journal of Health Psychology·Kenneth A Wallston
Feb 3, 2007·Arthritis and Rheumatism·Edward YelinPeter Panopalis
Feb 20, 2007·Lancet·David P D'CruzGraham R V Hughes
Feb 2, 2008·Arthritis and Rheumatism·Hermine I BrunnerEarl D Silverman
Oct 17, 2009·The Journal of Rheumatology·Linda T HirakiEarl D Silverman
Jan 30, 2010·Arthritis and Rheumatism·Philip J HashkesSuzanne L Bowyer
Aug 5, 2010·Nature Reviews. Rheumatology·Sylvia Kamphuis, Earl D Silverman
Sep 24, 2010·Lupus·S P ArdoinUNKNOWN APPLE investigators
Jul 29, 2011·Reumatología clinica·Graciela S Alarcón
Aug 5, 2011·Annals of the Rheumatic Diseases·M W HeijstekUNKNOWN EULAR
Feb 2, 2012·Arthritis and Rheumatism·Louise WatsonUNKNOWN UK Juvenile-Onset Systemic Lupus Erythematosus Study Group
May 9, 2012·Pediatric Clinics of North America·Deborah M Levy, Sylvia Kamphuis
Jun 26, 2012·Arthritis Care & Research·Clovis A SilvaHermine I Brunner
Jun 22, 2013·Seminars in Arthritis and Rheumatism·Emily J SuttonIan N Bruce
Aug 21, 2014·European Journal of Preventive Cardiology·Flavia BalloccaFiorenzo Gaita
Nov 17, 2015·The Journal of Rheumatology·Konstantinos TseliosMurray B Urowitz

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Citations

May 21, 2019·Current Opinion in Rheumatology·Jackeline Rodriguez-Smith, Hermine I Brunner
Sep 8, 2019·Current Rheumatology Reports·Janet E McDonagh, Albert Farre
Sep 30, 2018·Expert Review of Clinical Immunology·Claudia Elera-FitzcarraldManuel F Ugarte-Gil
Jul 30, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Louise OniKjell Tullus
Dec 15, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Liza J McCann, Christian M Hedrich
Mar 7, 2021·Journal of Clinical Medicine·Kai Liang TehThaschawee Arkachaisri
Jul 2, 2021·Pediatric Rheumatology Online Journal·Sirinthip KittivisuitSoamarat Vilaiyuk
Jul 11, 2021·Paediatric Drugs·Vitor Cavalcanti TrindadeClovis Artur Silva
Jan 1, 2022·Lupus Science & Medicine·Mohamed Javad WahadatSylvia Kamphuis
Jan 7, 2022·International Journal of Rheumatic Diseases·Kai Liang TehThaschawee Arkachaisri
Jan 23, 2022·Clinical Reviews in Allergy & Immunology·Xin HuangQianjin Lu

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Methods Mentioned

BETA
coronary bypass

Software Mentioned

SPSS Statistics

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