Long-Term Clinical Outcomes of High-Dose Mepolizumab Treatment for Hypereosinophilic Syndrome

The Journal of Allergy and Clinical Immunology. in Practice
Fei Li KuangAmy D Klion

Abstract

Conventional therapies for hypereosinophilic syndromes (HES) have variable efficacy and carry significant long-term toxicities. Anti-IL-5 (mepolizumab) therapy has a glucocorticoid (GC)-sparing effect in GC-sensitive HES, but the efficacy of mepolizumab in treatment-refractory HES patients with severe disease has not been examined to date. To identify predictors of response to mepolizumab in subjects with severe treatment-refractory HES and compare long-term outcomes in these subjects with HES subjects treated with conventional therapies. Retrospective analysis of clinical and laboratory data from 35 HES subjects treated with mepolizumab and 55 HES subjects on conventional therapy, all followed at a single center, was performed. Peak eosinophilia, GC sensitivity, pulmonary involvement, HES clinical subtype, and pretreatment serum IL-5 were correlated with mepolizumab response. Despite evidence of more severe disease at baseline, mepolizumab-treated subjects had comparable long-term clinical outcomes to HES subjects treated with conventional therapies and reported improvements in therapy-related comorbidities. Subjects managed with mepolizumab monotherapy had fewer disease flares than HES subjects on conventional therapies or me...Continue Reading

Citations

Apr 4, 2019·The New England Journal of Medicine·Fei Li KuangAmy D Klion
Jan 25, 2020·Annual Review of Pathology·Amy D KlionBruce S Bochner
Nov 20, 2019·Allergy, Asthma & Immunology Research·Ioana AgacheLiliana Rogozea
Jul 18, 2020·Nature Reviews. Cancer·Sharon Grisaru-TalAriel Munitz
Apr 20, 2019·The European Respiratory Journal·Laure TabèzeCamille Taillé
Oct 28, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Kindra StokesAmy D Klion
Jan 1, 2020·Respirology Case Reports·Ryota OtoshiTakashi Ogura
Mar 21, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J HaanenM Obeid
Oct 2, 2020·Chest·Chen E Rosenberg, Paneez Khoury
Feb 12, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Victoria EngJaved Sheikh
Mar 12, 2021·Multiple Sclerosis and Related Disorders·M JonakowskiM Matysiak
Mar 30, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Oded ShamrizYuval Tal
Nov 24, 2019·The Medical Clinics of North America·Fei Li Kuang
Apr 24, 2021·Seminars in Immunopathology·Fei Li Kuang, Bruce S Bochner
Mar 2, 2021·Annual Review of Immunology·Elizabeth A JacobsenMarc E Rothenberg
May 13, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Gildas BaulierMarion Malphettes
Jul 16, 2021·Journal of Cutaneous Medicine and Surgery·Lina BelmeskElena Netchiporouk
Oct 14, 2021·Clinics·José Mario Alves JúniorWanderley Marques Bernardo
Nov 13, 2021·Expert Review of Clinical Immunology·David Watchorn, Fernando Holguin

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