Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway

Life Sciences
Sajad JeddiAsghar Ghasemi

Abstract

A deficiency in hydrogen sulfide (H2S) and nitric oxide (NO) contributes to the development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has been reported in rats with T2D with co-administration of sodium nitrite and sodium hydrosulfide (NaSH); the underlying mechanisms have however not yet been elucidated. The aim of this study is to determine the long-term effects of co-administering sodium nitrite and NaSH on expression of genes involved in liver gluconeogenesis in rats with T2D. T2D was induced using a high fat diet combined with low-dose of streptozotocin (30 mg/kg). Rats were divided into 5 groups (n = 7/group): Control, T2D, T2D + nitrite, T2D + NaSH, and T2D + nitrite+NaSH. Nitrite (50 mg/L) and NaSH (0.28 mg/kg) were administered for 9 weeks. Intraperitoneal pyruvate tolerance test (PTT) was performed at the end of the ninth week and mRNA expressions of PI3K, Akt, eNOS, PEPCK, G6Pase, and FBPase were measured in the liver. Co-administration of nitrite and NaSH decreased elevated serum glucose concentrations during PTT. Compared to T2D + nitrite, co-administration of nitrite and NaSH resulted in significant increases in mRNA expression of PI3K, Akt, and eNOS and significant decreases in mRNA e...Continue Reading

References

Oct 1, 1992·The Journal of Clinical Investigation·I MagnussonG I Shulman
Jan 1, 1967·Biochimica Et Biophysica Acta·I SeidmanG W Teebor
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·A ValeraF Bosch
Aug 28, 1997·Biochemical and Biophysical Research Communications·R HosokiH Kimura
Jan 7, 2006·Journal of the American Society of Nephrology : JASN·Assaad EidAgnès Conjard
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Swasti TiwariCarolyn A Ecelbarger
Jul 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Varman T SamuelGerald I Shulman
Jul 16, 2009·Nitric Oxide : Biology and Chemistry·Catherine N Hall, John Garthwaite
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mattias CarlströmJon O Lundberg
Feb 1, 2011·Free Radical Biology & Medicine·Xinggui ShenChristopher G Kevil
Oct 13, 2012·Journal of Cellular Biochemistry·Rodrigo GaticaAlejandro J Yáñez
Nov 16, 2012·Research in Veterinary Science·Yulin YanYongke Sun
Oct 26, 2013·Free Radical Biology & Medicine·Hong JiangNathan S Bryan
Feb 17, 2015·World Journal of Gastroenterology : WJG·Bergthor BjörnssonPer Sandström
May 13, 2015·Nature Communications·Paul M TitchenellMorris J Birnbaum
Aug 15, 2015·Biochimica Et Biophysica Acta·YoungJun JuGuangdong Yang
Sep 25, 2015·Antioxidants & Redox Signaling·Ashley A UntereinerLingyun Wu
Oct 28, 2016·American Journal of Physiology. Cell Physiology·Csaba Szabo
Jan 17, 2017·Nitric Oxide : Biology and Chemistry·Sevda GheibiAsghar Ghasemi
Feb 6, 2017·American Journal of Physiology. Cell Physiology·Nancy L KanagyAndreas Papapetropoulos
Jul 13, 2017·Antioxidants & Redox Signaling·Ashley Untereiner, Lingyun Wu
Oct 27, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hanieh GholamiAsghar Ghasemi
Feb 6, 2018·Biochemical Pharmacology·Khosrow Kashfi
Mar 3, 2018·Diabetes Research and Clinical Practice·N H ChoB Malanda
Jul 5, 2018·Cell Metabolism·Jon O LundbergEddie Weitzberg
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Isabel Cordero-HerreraMattias Carlstrom
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sevda GheibiAsghar Ghasemi

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
Toshiji SaibaraSaburo Onishi
Expert Opinion on Investigational Drugs
Sarra SmatiBertrand Cariou
International Journal of Molecular Sciences
Yoshio SumidaJapan Study Group Of Nafld Jsg-Nafld
© 2021 Meta ULC. All rights reserved