Long-term cognitive and EEG effects of tiagabine in drug-resistant partial epilepsy

Epilepsy Research
R KälviäinenP J Riekkinen

Abstract

A new anti-epileptic drug, tiagabine, is a potent inhibitor of GABA uptake into neurons and glia. Tiagabine has shown promising efficacy and safety profiles as add-on treatment for partial seizures. We evaluated the long-term effects of tiagabine on cognition and EEG in 37 patients with partial epilepsy. The study protocol consisted of a randomized, double-blind, placebo-controlled, parallel-group add-on study and an open-label extension study. During the 3 month double-blind phase at low doses (30 mg/day) tiagabine treatment did not cause any cognitive or EEG changes as compared with placebo. Tiagabine treatment did not cause deterioration in cognitive performance or produce any rhythmic slow-wave activity or other constant, new abnormalities on EEG during longer follow-up with successful treatment on higher doses after 6-12 months (mean 65.7 mg/day, range 30-80 mg/day) and after 18-24 months (mean dose 67.6 mg/day, range 24-80 mg/day). The daily dosages in the long-term follow-up of the present study are higher than in the previous reports.

References

Jan 1, 1991·Trends in Neurosciences·V Crunelli, N Leresche
Apr 24, 1991·European Journal of Pharmacology·E B NielsenC Braestrup
Jan 1, 1989·British Journal of Clinical Pharmacology·B S Meldrum
Apr 1, 1984·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J Engel
Dec 1, 1993·Drugs·R KälviäinenP J Riekkinen
Mar 1, 1994·Seizure : the Journal of the British Epilepsy Association·S SveinbjornsdottirJ S Duncan
Jan 1, 1995·Epilepsia·I E Leppik
Mar 28, 1996·European Journal of Pharmacology·T HalonenA Pitkänen

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Citations

Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J M Pellock, L D Morton
Oct 19, 2007·Neuropsychology Review·David W LoringKimford J Meador
Oct 1, 1995·Epilepsy Research·M AikiäP J Riekkinen
Apr 12, 2005·Epilepsy & Behavior : E&B·N FritzC Helmstaedter
Jun 26, 2001·Epilepsia·A P Aldenkamp
Aug 25, 2001·Epilepsia·R Kälviäinen
Jun 26, 2003·Epilepsia·Albert P AldenkampRianne Reijs
May 1, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·E J Novotny
Aug 11, 2000·Paediatric Drugs·B Bar-OzS Ito
Feb 20, 2002·British Journal of Clinical Pharmacology·John S Duncan
Feb 5, 1998·Lancet·J P Leach, M J Brodie
Oct 13, 2006·The Journal of Pharmacy and Pharmacology·Bogusława Pietrzak, Elzbieta Czarnecka
Dec 21, 2004·Pediatric Neurology·Romaine Schubert
Dec 27, 2005·Epilepsy Research·Kimford J Meador
Jun 19, 2013·Epilepsy & Behavior : E&B·David G VosslerUNKNOWN Postmarketing Antiepileptic Drug Survey (PADS) group study investigators
Mar 1, 2000·Drug Metabolism and Drug Interactions·H KastbergK Wesnes
Dec 14, 2011·Therapeutic Advances in Neurological Disorders·Clare M EddyAndrea E Cavanna
Jan 1, 1997·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·C D Ferrie, J H Livingston
Apr 16, 2002·Journal of Child Neurology·Blaise F D Bourgeois
Jul 29, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·I C Wong, S D Lhatoo
Feb 7, 2014·The Cochrane Database of Systematic Reviews·Jennifer PulmanAnthony G Marson
Apr 29, 1998·Current Opinion in Neurology·J W Sander
Oct 15, 2019·The Cochrane Database of Systematic Reviews·Rebecca BresnahanAnthony G Marson

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