Long-term cognitive trajectories and heterogeneity in patients with schizophrenia and their unaffected siblings

Acta Psychiatrica Scandinavica
Md A IslamGROUP Investigators

Abstract

This study aimed to assess the heterogeneity and stability of cognition in patients with a non-affective psychotic disorder and their unaffected siblings. In addition, we aimed to predict the cognitive subtypes of siblings by their probands. Assessments were conducted at baseline, 3 and 6 years in 1119 patients, 1059 siblings and 586 controls from the Genetic Risk and Outcome of Psychosis (GROUP) study. Group-based trajectory modeling was applied to identify trajectories and clustered multinomial logistic regression analysis was used for prediction modeling. A composite score of eight neurocognitive tests was used to measure cognitive performance. Five stable cognitive trajectories ranging from severely altered to high cognitive performance were identified in patients. Likewise, four stable trajectories ranging from moderately altered to high performance were found in siblings. Siblings had a higher risk of cognitive alteration when patients' alteration was mild (OR = 2.21), moderate (OR = 5.70), and severe (OR = 10.07) compared with patients with intact cognitive function. The familial correlation coefficient between pairs of index patients and their siblings was 0.27 (P = 0.003). The cognitive profiles identified in the curre...Continue Reading

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Citations

Jun 4, 2020·Early Intervention in Psychiatry·Veronika VoráčkováPavel Mohr
Apr 18, 2021·Asian Journal of Psychiatry·Mariachiara BuonocoreRoberto Cavallaro
May 23, 2021·Journal of Psychiatric Research·Diego Barreto RebouçasClarissa Severino Gama
Jul 23, 2020·Translational Psychiatry·Tesfa Dejenie HabtewoldBehrooz Z Alizadeh

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Software Mentioned

SAS ( Statistical Analysis System )
GBTM

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