Long-term cognitive treatment of Alzheimer's disease: a single case study

Neuropsychological Rehabilitation
Alberto Luis FernándezAngel A Monti

Abstract

The effects of long-term treatment in a demented patient were evaluated in this study. One individual diagnosed with Alzheimer's dementia (AD) was treated with neuropsychological rehabilitation techniques as well as drugs for a period of 2 years and 10 months. An A-B-A-B design was performed for the cognitive treatment. Neuropsychological treatment consisted of a combination of direct re-training and training in activities of daily living. Cognitive performance was monitored with the Mattis Dementia Rating Scale. Results showed improvement and a slower decline during the treatment phases (A) as compared to the no-treatment phases (B). The Conceptualisation and Attention subscales benefited most followed by the Memory subscale. Long-term treatment was shown to be effective in AD. Although cognitive drugs may have been beneficial neuropsychological rehabilitation played an important role in the success of this treatment, appearing as a necessary condition.

References

Mar 1, 1987·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·J T BeckerK L McGonigle-Gibson
Nov 1, 1969·British Journal of Preventive & Social Medicine·H B Newcombe
Aug 1, 1969·Planta medica·F Newcombe, B A Patel
Nov 1, 1984·The American Journal of Psychiatry·W G RosenK L Davis
Mar 29, 2001·European Journal of Endocrinology·G E Krassas, A E Heufelder
Apr 11, 2001·Journal of Clinical Child Psychology·A E Kazdin
Aug 15, 2001·Neurology·B WinbladUNKNOWN Donepezil Nordic Study Group
Feb 28, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·O L LopezS T DeKosky
May 2, 2002·Acta Neurologica Scandinavica·Elisabetta FarinaC Mariani
Apr 4, 2003·The New England Journal of Medicine·Barry ReisbergUNKNOWN Memantine Study Group

❮ Previous
Next ❯

Citations

Mar 31, 2009·Journal of Gerontological Nursing·Fang YuSharon E McKenzie
Oct 4, 2012·Developmental Neurorehabilitation·Giulio E LancioniNadia Zonno
Oct 10, 2013·Developmental Neurorehabilitation·Alessandro O CaffòAndrea Bosco
Oct 22, 2016·The Clinical Neuropsychologist·Alberto Luis FernandezJuan Carlos Arango-Lasprilla
May 21, 2013·American Journal of Alzheimer's Disease and Other Dementias·Viviana PerilliDoretta Oliva
Dec 25, 2008·American Journal of Alzheimer's Disease and Other Dementias·Giulio E LancioniMauro G Minervini
Mar 27, 2009·American Journal of Alzheimer's Disease and Other Dementias·Giulio E LancioniMauro G Minervini
Jun 7, 2013·The Cochrane Database of Systematic Reviews·Alex Bahar-FuchsBob Woods

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.