Long-term consequences of prenatal exposure to lead on brain development in rats

Neuroscience and Behavioral Physiology
B Ya RyzhavskiiS N Baranova

Abstract

Administration of singe doses of lead citrate (200 mg/kg) to pregnant rats (on day 18 of pregnancy) was followed by the appearance of destructive changes in brains at age 40 days, with cysts, foci of gliocyte proliferation, pyknotic neurons, and decreases in NADH and NADPH diaphorase activities in neocortical and hippocampal neurons. Decreases in the density of neurons in the cortex and decreases in cortical thickness were also observed. The intensity of free-radical oxidation in the cortex increased three-fold, along with a 3.9-fold increase in the concentration of lipid peroxides, providing evidence of oxidative stress. The possible mechanisms by which these alterations develop are analyzed.

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Citations

Jun 10, 2019·Bulletin of Experimental Biology and Medicine·B Ya RyzhavskiiO V Lazinskaya
Mar 2, 2018·Environmental Science and Pollution Research International·Swetha ChintapantiP Sreenivasula Reddy
Dec 29, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R P Jaya PrasanthiG Rajarami Reddy
Feb 14, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D Chand BashaG Rajarami Reddy
Jun 7, 2011·Chemosphere·Hilda Cornejo-GarridoJaviera Cervini-Silva

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