PMID: 6402060Jan 22, 1983Paper

Long-term continuous intraperitoneal insulin treatment in brittle diabetes

British Medical Journal
G PozzaA E Pontiroli

Abstract

Attempts to achieve a fair metabolic equilibrium in a young woman with brittle diabetes by continuous subcutaneous, intramuscular, and continuous intravenous administration of insulin were unsuccessful. Continuous intraperitoneal administration of insulin through a permanently inserted polyethylene catheter connected to an open-loop peristaltic pump led to an appreciable improvement in mean blood glucose concentration, mean amplitude of glycaemic excursions, and M value and to normalisation of intermediate metabolic products. The peritoneal catheter was well tolerated for over 120 days without appreciable adverse effects. This case suggests that long-term intraperitoneal administration of insulin is a feasible therapeutic approach in the management of brittle diabetes.

Citations

Nov 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·J L Selam
Aug 1, 1985·Diabetologia·G V GillK G Alberti
Apr 20, 1985·British Medical Journal·G A Coles
Jul 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·D J HusbandK G Alberti
Jul 6, 2019·Endocrine Reviews·Rayhan A LalBruce Buckingham
Aug 10, 1989·The New England Journal of Medicine·B Zinman
May 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·H TindallJ A Davies
Nov 1, 1993·Artificial Organs·K WaxmanK H Nguyen

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