Long-term contraception in a small implant: A review of Suprelorin (deslorelin) studies in cats

Journal of Feline Medicine and Surgery
Christelle Fontaine

Abstract

Deslorelin (Suprelorin®; Virbac) is a gonadotropin-releasing hormone (GnRH) agonist licensed in select countries for the long-term suppression of fertility in adult male dogs and male ferrets. This article summarizes studies investigating the use of deslorelin implants for the long-term suppression of fertility in male and female domestic cats. Slow-release deslorelin implants have been shown to generate effective, safe and reversible long-term contraception in male and female cats. In pubertal cats, a 4.7 mg deslorelin implant suppressed steroid sex hormones for an average of approximately 20 months (range 15-25 months) in males and an average of approximately 24 months (range 16-37 months) in females. Reversibility has been demonstrated by fertile matings approximately 2 years post-treatment in both male and female adult cats. In prepubertal female cats of approximately 4 months of age, puberty was postponed to an average of approximately 10 months of age (range 6-15 months) by a 4.7 mg deslorelin implant. The large variability in the duration of suppression of gonadal activity makes the definition of the optimal time for reimplantation quite challenging. In addition, the temporary stimulation phase occurring in the weeks fol...Continue Reading

References

Jun 16, 2005·Animal Reproduction Science·A M Padula
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·S Rubion, M A Driancourt
Feb 18, 2012·Reproduction in Domestic Animals = Zuchthygiene·A RissoC Gobello
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Jun 21, 2014·Reproduction in Domestic Animals = Zuchthygiene·S Goericke-PeschP Georgiev

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Citations

Jan 7, 2016·Journal of Feline Medicine and Surgery·Fiona Hollinshead, Natali Krekeler
May 15, 2018·Journal of the American Animal Hospital Association·Elizabeth A Layne, Renee V Richmond
Nov 16, 2018·Reproduction in Domestic Animals = Zuchthygiene·Silke M HaenOlli A T Peltoniemi
Feb 23, 2020·Journal of Feline Medicine and Surgery·Etienne FurthnerAlain Fontbonne
Apr 7, 2017·Journal of Veterinary Pharmacology and Therapeutics·L P KaneS Cox
Jun 17, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Mary K AgnewVeronica B Cowl
Oct 6, 2021·Reproduction in Domestic Animals = Zuchthygiene·L Ferré-DolcetS Romagnoli

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Methods Mentioned

BETA
sedation
contraception

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