PMID: 8927039Dec 6, 1995

Long-term correction of STZ-diabetic rats after short-term i.p. VOSO4 treatment: persistence of insulin secreting capacities assessed by isolated pancreas studies

Molecular and Cellular Biochemistry
P PoucheretG H Cros

Abstract

We have previously shown that 3 week oral VOSO4 treatment of streptozotocin (STZ, 60 mg/kg)-induced diabetic rats was able to correct diabetes for 13 weeks after treatment withdrawal. In the present study, we investigated whether a short-term (8 days) i.p. VOSO4 treatment was similarly able to reverse the diabetic state. Insulin secretory capacities were assessed at distance of treatment using the isolated pancreas preparation. Seven treatment-groups were performed: high dose VOSO4-treated diabetics (HVD, 1.3 mM/kg/8 days), food-restricted diabetics (FRD, food adjusted to HVD levels), low dose VOSO4-treated diabetes (LVD, 0.06 mM/kg/day), insulin-treated diabetics (ID, dose adjusted to normalize glycaemia) and VOSO4 (0.06 mM/kg/day) + insulin (dose adjusted to normalize glycaemia in the presence of vanadium)-treated diabetics (IVD), in addition to the corresponding untreated non-diabetic controls (C) and diabetics (D). Our results indicate that long-term correction of diabetes (a) can be obtained after an 8 day treatment using i.p. VOSO4 in diabetic animals retaining some degree of pancreatic function, (b) is not obtained with insulin treatment or food restriction although the association of VOSO4 and insulin was found benefici...Continue Reading

Citations

May 1, 1992·Diabetes Research and Clinical Practice·E GuastamacchiaG M Nardelli
Apr 1, 1991·The Journal of Clinical Investigation·J MeyerovitchC R Kahn
Oct 1, 1991·Diabetes·J E Rodríguez-GilJ J Guinovart
Sep 1, 1990·The Journal of Endocrinology·H SakuraiJ Kawada
Apr 1, 1990·Canadian Journal of Physiology and Pharmacology·S RamanadhamJ H McNeill
Dec 1, 1987·Diabetes·J A FaginS R Levin
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Mar 15, 1982·The Biochemical Journal·L Agius, W J Vaartjes
Feb 1, 1994·Pharmacology & Toxicology·S DaiJ H McNeill

Related Concepts

Derivatives
Benign Tumor of Pancreas
Vanadyl sulfate
Insulin B Chain
Streptozotocin Diabetes
Insulin Secretion
Pancreatic Diseases
Corrective
Vanadium Compounds
Cell Secretion

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