Long-term Course of Alzheimer Disease in Patients Treated According to the Dutch Dementia Guideline at a Memory Clinic: A "Real-Life" Study

Alzheimer Disease and Associated Disorders
Erika DroogsmaPeter P De Deyn

Abstract

There is little knowledge of the long-term course of Alzheimer disease (AD) in light of current pharmacological and nonpharmacological interventions provided in a "real-life" setting. The Frisian Alzheimer's Disease Cohort study is a "real-life" study of the course of AD in patients (n=576) treated with pharmacological (ie, cholinesterase inhibitors) and nonpharmacological (ie, case management, respite care) interventions. Disease course was described by changes in cognition (Mini Mental State Examination, clock-drawing test) and number of types of professional care applying a repeated-measures analysis using a marginal model (population-based average model). In addition, behavioral and psychological symptoms, and proportions of nursing home admissions and deaths were investigated. During 3.5 years, the average Mini Mental State Examination decreased from 22.24 to 18.91, the clock-drawing test score increased from 3.38 to 4.05, the number of types of professional care increased from 0.85 to 2.64, and the patients with behavioral and psychological symptoms increased from 29.0% to 70.2%. The proportion of patients admitted to a nursing home was 40.8% and 41.0% died. Cognition and behaviour of AD patients deteriorated accompanied ...Continue Reading

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Citations

Aug 20, 2019·Journal of Alzheimer's Disease : JAD·Valory N PavlikEveleen Darby
Feb 5, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bing Han, Chengwei He

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Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
Statistical Analysis Software ( SAS )
SAS

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