Long-term Course of Depression Trajectories in Patients With COPD: A 3-Year Follow-up Analysis of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Cohort

Chest
Abebaw M YohannesEmil F M Wouters

Abstract

There is insufficient evidence about the long-term course of depressive symptom trajectories and their impact among patients with COPD. We analysed 3-year data obtained from patients with COPD participating in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study. Patients were split into four groups on the basis of Center for Epidemiologic Studies Depression Scale score (< 16 vs ≥ 16) and antidepressant use (yes vs no) at baseline and at 3 years: never depressed, new onset, remittent, and persistent depression. Baseline characteristics were used to assess factors associated with the group by using logistic regression. A total of 1,589 patients with COPD completed the 3-year follow-up. Of these, 55% (n = 869) were classified as never depressed, 24% (n = 377) were classified as persistently depressed, 14% (n = 226) developed new onset of depression, and 7% (n = 117) had depression that remitted. Female sex and history of stroke were associated with substantial increases in the odds of persistent depression (OR, 2.95; 95% CI, 2.05-4.24 and OR, 3.09; 95% CI, 1.43-6.67, respectively). Odds of new onset depression increased with worse health status (OR, 1.10; 95% CI, 1.04-1.17 per 4-point increase in...Continue Reading

References

Oct 6, 2009·Chest·Cornelia SchneiderChristoph R Meier
Jun 1, 2008·Expert Review of Respiratory Medicine·Abebaw Mengistu Yohannes
Oct 5, 2010·American Journal of Respiratory and Critical Care Medicine·Nicola A HananiaUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study investigators
Nov 16, 2011·Expert Review of Respiratory Medicine·Abebaw Mengistu Yohannes, Martin Joseph Connolly
Jan 17, 2012·American Journal of Respiratory and Critical Care Medicine·Catherine LaurinKim L Lavoie
Feb 9, 2013·The British Journal of Psychiatry : the Journal of Mental Science·George S AlexopoulosPatrick J Raue

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Citations

Apr 27, 2016·Expert Review of Respiratory Medicine·Denis E O'DonnellJ Alberto Neder
Oct 25, 2016·Journal of Psychosomatic Research·A M Yohannes
Jul 29, 2018·The European Respiratory Journal·Abebaw Mengistu Yohannes
Jun 25, 2020·Expert Review of Respiratory Medicine·Abebaw Mengistu Yohannes
Sep 21, 2020·Aging Clinical and Experimental Research·Panaiotis FinamoreMartijn A Spruit
Nov 26, 2016·International Journal of Palliative Nursing·Andy ParryAoife Gleeson
May 6, 2017·British Journal of Health Psychology·Coby AnnemaAdelita V Ranchor
Aug 28, 2020·Geriatrics·Ting-Fen Lin, Samantha Shune
Dec 17, 2020·Expert Review of Respiratory Medicine·Abebaw Mengistu YohannesVincent S Fan
Jul 25, 2017·Journal of the American Medical Directors Association·Abebaw Mengistu YohannesNicola A Hanania
Aug 7, 2021·Clinics in Chest Medicine·Christine Jenkins

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