PMID: 2222011Oct 1, 1990Paper

Long-term course of patients with persistent hypercalcitoninemia after apparent curative primary surgery for medullary thyroid carcinoma

Annals of Surgery
J A van HeerdenD M Ilstrup

Abstract

Thirty-one patients with persistent hypercalcitoninemia after seemingly adequate primary operation for medullary thyroid carcinoma (MTC) were followed for a mean period of 11.9 years after operation. Ten patients had sporadic MTC and the remaining patients were members of families with multiple endocrine neoplasia (MEN)--either MEN 2A (15 patients) or MEN 2B (six patients). Overall 5- and 10-year survival rates were 90% and 86%, respectively. Only four patients died at the completion of the study: two of MTC and two of unrelated causes. Eleven patients (35.5%) underwent surgical re-exploration after demonstration of recurrent disease clinically or radiologically. In no patient did the calcitonin level return to normal after re-exploration. The presence of more than three metastatic nodes at the time of initial operation was a statistically significant (p = 0.003) predictor for disease recurrence. Factors approaching statistical significance were patients younger than age 35 (p = 0.06) and the percentage of cells in the S phase of cell division (0.07). This data supports a conservative surgical philosophy in the management of the patient with persistent hypercalcitoninemia after resection of MTC.

References

Aug 2, 1979·The New England Journal of Medicine·D L TrumpS B Baylin
Apr 1, 1978·Clinical Nuclear Medicine·R J AndersonJ A Carney
Aug 1, 1986·World Journal of Surgery·A MiyauchiM Maeda
Jul 1, 1988·AJR. American Journal of Roentgenology·C C ReadingM R Hurt
Jun 27, 1964·Nature·G V FOSTERI MACINTYRE

❮ Previous
Next ❯

Citations

Jun 1, 2000·Cancer Control : Journal of the Moffitt Cancer Center·G W Randolph, D Maniar
Jul 1, 1995·Journal of Surgical Oncology·L A MarzanoL Zarrilli
Sep 1, 1993·Seminars in Surgical Oncology·D L Fraker, J A Norton
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·N NeuholdB Niederle
Feb 27, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·O Gimm, H Dralle
Nov 2, 2004·World Journal of Surgery·Jörg UkkatHenning Dralle
Mar 5, 2013·Langenbeck's Archives of Surgery·Henning DralleUNKNOWN German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hem
Jun 12, 2002·Current Treatment Options in Oncology·E Kebebew, O H Clark
Aug 29, 2003·Current Treatment Options in Oncology·Jeffrey F Moley
Jun 22, 2005·Current Treatment Options in Oncology·Amber Traugott, Jeffrey F Moley
Jun 22, 2005·Current Treatment Options in Oncology·Frank Jay Quayle, Jeffrey F Moley
Jun 23, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Isabel Peixoto CallejoJorge Rosa Santos
Oct 1, 1995·Trends in Endocrinology and Metabolism : TEM·D L LearoydB G Robinson
Mar 15, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·B ErikssonB Långström
Jul 1, 1997·The American Journal of Medicine·H M HeshmatiG W Sizemore
Jan 5, 2001·The Surgical Clinics of North America·J E GervasoniB Cady
Feb 14, 2003·Lancet·Steven I Sherman
Jul 27, 2002·The Lancet Oncology·Louiza Vini, Clive Harmer
Dec 18, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Martin SchlumbergerMassimo Santoro
Dec 17, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Giuseppe CostanteSebastiano Filetti
Oct 9, 2001·Clinical Endocrinology·S FrancUNKNOWN French Medullary Study Group (GETC)
Jul 29, 1998·Journal of Internal Medicine·J F MoleyS A Wells
Aug 21, 2002·Thyroid : Official Journal of the American Thyroid Association·N FershtC Harmer
Jan 5, 2002·Thyroid : Official Journal of the American Thyroid Association·A IdeK Eguchi
Oct 1, 1995·Thyroid : Official Journal of the American Thyroid Association·D J MarshB G Robinson
Jul 21, 1998·Thyroid : Official Journal of the American Thyroid Association·M E GirelliB Busnardo
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·J K RoneM D Grinkemeyer
Jun 3, 2005·Thyroid : Official Journal of the American Thyroid Association·H M van SantenT Vulsma
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Jun 1, 1997·Annals of Surgery·J F MoleyM K DeBenedetti
Nov 24, 1999·Annals of Surgery·J B FlemingD B Evans
May 25, 2006·Current Opinion in Pediatrics·Melissa E Danko, Michael A Skinner
Jul 3, 2008·Annals of Surgical Oncology·Maya D LeggettSteve R Martinez
Oct 8, 2009·Annals of Surgical Oncology·Ashok R Shaha, R Michael Tuttle
Jun 8, 2004·Acta chirurgica Iugoslavica·V ZivaljevićM Havelka
Jun 8, 2004·Acta chirurgica Iugoslavica·M MalesevićS Popadic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.