Long-term cyclosporine treatment: evaluation of serum biochemical parameters and histopathological alterations in Wistar rats

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Ana Elisa BöhmerDiogo Onofre Souza

Abstract

The immunosuppressant agent cyclosporine (CsA) is currently used in transplanted patients and in the therapy of autoimmune disorders. CsA treatment has significant acute and chronic side effects on the liver and kidney. However, in the clinical setting, it is difficult to distinguish a direct effect of CsA treatment from other confounding variables, such as allograft rejection and effects due to other drug therapies. In the present study, we assessed for direct associations between CsA immunosuppressive therapy and cytokines levels, kidney and liver functionality, as well as lung histopathological status in rats submitted to chronic CsA treatment without undergoing any transplantation. Male Wistar rats were divided into three groups. The control group received vehicle (corn oil), and treated groups received CsA 5 or 15 mg/kg, by daily gastric gavage during 8 weeks. The results demonstrated that CsA treatment decreases blood levels of interleukins 1α (IL-1α), 1β (IL-1β) and interleukin 2 (IL-2), but does not alter interleukin 6 (IL-6) and IFN-γ levels. Serum biochemical markers of renal (creatinine) and hepatic (SGPT and SGOT) injury/dysfunction did not vary with CsA treatment, despite the presence of small histological alterati...Continue Reading

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Citations

Feb 15, 2013·BMC Complementary and Alternative Medicine·Karine M FreitasHeidi Dolder
Sep 18, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ashima GulatiArvind Bagga
Dec 11, 2013·Environmental Toxicology and Pharmacology·Deepa K IngawaleSuresh R Naik
Mar 5, 2013·Respiratory Physiology & Neurobiology·Andrea PorzionatoRaffaele De Caro
Oct 5, 2014·The Journal of Surgical Research·Sami AkbulutYusuf Turkoz
Mar 26, 2015·Anais Da Academia Brasileira De Ciências·Karine M de FreitasHeidi Dolder
May 31, 2017·Experimental Physiology·Denize Jussara Rupolo Dall'AgnolMadileine Francely Américo

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