Long-term death and recurrence in patients with acute venous thromboembolism: the MASTER registry

Thrombosis Research
Melina VersoMASTER investigators

Abstract

The long-term clinical outcome of VTE has been essentially assessed in cohorts of selected patients. The aim of this multicenter registry was to prospectively assess the long-term clinical outcome in a cohort of unselected patients with objectively confirmed acute VTE. Death and VTE recurrence at 24 months were the main study outcomes. Univariate and multivariate survival analyses were performed according to the Kaplan-Meyer and Cox proportional hazard model, respectively. 2119 patients with acute VTE were included in the registry: 1541 (72.7%) with deep vein thrombosis, 206 (9.7%) with pulmonary embolism and 372 (17.6%) with both. Information about death was available in 2021 patients (95.4%) and about recurrence in 1988 patients (93.8%). 167 patients (4.55% patient-year) died during follow-up. After adjusting for age, cancer (Hazard ratio [HR]: 7.2; 95%CI 4.8-10.8), long-term heparin treatment (HR: 2.5; 95%CI 1.8-3.5), in-hospital management of VTE (HR: 2.0; 95%CI 1.3-3.0), and ileo-caval thrombosis (HR: 1.7; 95%CI 1.2-2.4) were found to be independent predictors of death. 124 (3.63% patient-year) patients had a VTE recurrence during follow-up. In-hospital management of VTE (HR: 1.8; 95%CI 1.2-2.9), male gender (HR: 1.7; 95%C...Continue Reading

Associated Clinical Trials

Citations

Nov 28, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charlotte DentanJean-Luc Bosson
Oct 16, 2014·The American Journal of Emergency Medicine·Charles V Pollack
Jun 17, 2015·Nature Reviews. Cardiology·John A Heit
Jan 19, 2016·Journal of Thrombosis and Thrombolysis·John A HeitRichard H White
Dec 13, 2016·Journal of Thrombosis and Haemostasis : JTH·N ArshadS K Braekkan
Jul 29, 2017·European Heart Journal Supplements : Journal of the European Society of Cardiology·Carlo D'AgostinoAntonella Tufano
Jan 10, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Mashio NakamuraTetsuhito Kojima
Nov 21, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mickael HiligsmannJean-Yves Reginster
Aug 23, 2020·European Journal of Internal Medicine·Alexander T CohenUNKNOWN ETNA-VTE-Europe investigators
Feb 1, 2020·Chest·Matteo Giorgi-PierfranceschiUNKNOWN RIETE researchers
Oct 19, 2021·Frontiers in Cardiovascular Medicine·Henning NiliusMichael Nagler

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